Elaine Cheng
Yale University
22 Papers
491 Citations
Elaine Cheng is an academic researcher from Yale University. The author has contributed to research in topics: Melanoma & Endoplasmic reticulum. The author has an hindex of 20, co-authored 22 publications.
Chat about Author
Papers
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Michael Krauthammer,Yong Lin Kong,Byung Hak Ha,Perry Evans,Antonella Bacchiocchi,James P. McCusker,Elaine Cheng,Matthew J. Davis,Gerald Goh,Murim Choi,Stephan Ariyan,Deepak Narayan,Ken Dutton-Regester,Ken Dutton-Regester,Ana Capatana,Edna C. Holman,Marcus Bosenberg,Mario Sznol,Harriet M. Kluger,Douglas E. Brash,David F. Stern,Miguel A. Materin,Roger S. Lo,Shrikant Mane,Shuangge Ma,Kenneth K. Kidd,Nicholas K. Hayward,Richard P. Lifton,Joseph Schlessinger,Titus J. Boggon,Ruth Halaban +30 more
TL;DR: In this article, the authors characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas and found that sun-exposed melanomas had markedly more ultraviolet-like C>T somatic mutations compared to sun-shielded acral, mucosal and uveal melanomas.
1.1K
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.
Keith S. Hoek,David L. Rimm,Kenneth R. Williams,Hongyu Zhao,Stephan Ariyan,Aiping Lin,Harriet M. Kluger,Aaron Berger,Elaine Cheng,E. Sergio Trombetta,Terence Wu,Michio Niinobe,Kazuaki Yoshikawa,Gregory E. Hannigan,Ruth Halaban +14 more
TL;DR: A comprehensive view of changes in advanced melanoma relative to normal melanocytes is provided and new targets that can be used in assessing prognosis, staging, and therapy of melanoma patients are revealed.
485
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
Michael Krauthammer,Yong Kong,Antonella Bacchiocchi,Perry Evans,Natapol Pornputtapong,Cen Wu,James P. McCusker,Shuangge Ma,Elaine Cheng,Robert Straub,Merdan Serin,Marcus Bosenberg,Stephan Ariyan,Deepak Narayan,Mario Sznol,Harriet M. Kluger,Shrikant Mane,Joseph Schlessinger,Richard P. Lifton,Ruth Halaban +19 more
TL;DR: It is concluded that NF1 is a key tumor suppressor lost in melanomas, and that concurrent RASopathy gene mutations may enhance its role in melanomagenesis.
392
Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032
Jill C. Rubinstein,Mario Sznol,Anna C. Pavlick,Stephan Ariyan,Elaine Cheng,Antonella Bacchiocchi,Harriet M. Kluger,Deepak Narayan,Ruth Halaban +8 more
TL;DR: Evidence is presented that a patient bearing the BRAf V600K mutation responded remarkably to PLX4032, suggesting that clinical trials should include all patients with activating BRAF V600E/K mutations.
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
Ruth Halaban,Elaine Cheng,Yuhua Zhang,Gisela Moellmann,Douglas Hanlon,Marek Michalak,Vijayasaradhi Setaluri,Daniel N. Hebert +7 more
TL;DR: In this paper, the authors investigated whether the loss of tyrosinase was due to proteolytic degradation, and they found that the degradation process was more prominent in malignant than in normal melanocytes and promoted the maturation and transit from the ER to the Golgi compartment.