Einar Solheim
University of Bergen
40 Papers
461 Citations
Einar Solheim is an academic researcher from University of Bergen. The author has contributed to research in topics: Metabolite & Chemistry. The author has an hindex of 22, co-authored 40 publications.
Chat about Author
Papers
•Journal Article
Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.
TL;DR: Significant amounts of drugs could be detected in lung, heart, ovary, and intestinal wall 14 months after withdrawal of tamoxifen, demonstrating efficient retention and slow washout of these compounds in human tissue.
•Journal Article
Distribution of 4-Hydroxy-N-desmethyltamoxifen and Other Tamoxifen Metabolites in Human Biological Fluids during Tamoxifen Treatment
Ernst A. Lien,Einar Solheim,Oscar A. Lea,Steinar Lundgren,Stener Kvinnsland,Per Magne Ueland +5 more
TL;DR: Several metabolites of tamoxifen, including 4-hydroxylated, conjugated metabolites (Y, B, and BX), and N-desdimethyltamxifen (metabolite Z) were identified and their concentrations determined in fluids and feces from patients receiving chronic tamox ifen treatment, suggesting that the serum levels are production rate limited.
242
Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients.
TL;DR: This is the first report on the distribution of tamoxifen and metabolites into human brain and brain tumour, and the data form a basis for further investigation into the therapeutic effects of tamxifen on brain metastases from breast cancer.
160
Identification of organic eluates from four polymer‐based dental filling materials
TL;DR: The diversity of eluates from the four materials under study is demonstrated and, due to variation between the materials, the biocompatibility including the allergenic potential may be different.
145
Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry.
TL;DR: This method based on liquid chromatography-tandem mass spectrometry measures all known plasma forms of vitamins B(6) and B(2), which span a wide range of polarity.