Eileen Villasante
Naval Medical Research Center
33 Papers
100 Citations
Eileen Villasante is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Antigen & Malaria vaccine. The author has an hindex of 10, co-authored 27 publications. Previous affiliations of Eileen Villasante include Walter Reed Army Institute of Research.
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Papers
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine
Judith E. Epstein,Kristopher M. Paolino,Thomas L. Richie,Martha Sedegah,Alexandra Singer,Adam Ruben,Sumana Chakravarty,April Stafford,Richard C. Ruck,Abraham G. Eappen,Tao Li,Peter F. Billingsley,Anita Manoj,Joana C. Silva,Kara A. Moser,Robin Nielsen,Donna Tosh,Susan Cicatelli,Harini Ganeshan,Jessica Case,Debbie Padilla,Silas A. Davidson,Lindsey S. Garver,Elizabeth Saverino,Tooba Murshedkar,Anusha Gunasekera,Patrick S. Twomey,Sharina Reyes,James E. Moon,Eric R. James,Natasha Kc,Minglin Li,Esteban Abot,Arnel Belmonte,Kevin Hauns,Maria Belmonte,Jun Huang,Carlos S. Vasquez,Shon Remich,Mary Carrington,Yonas Abebe,Amy Tillman,Bradley Hickey,Jason A. Regules,Eileen Villasante,B. Kim Lee Sim,Stephen L. Hoffman +46 more
TL;DR: It is demonstrated for the first time to the authors' knowledge that PfSPZ Vaccine can protect against a 3-week heterologous CHMI in a limited group of malaria-naive adult subjects and provides a foundation for developing an optimized immunization regimen for preventing malaria.
Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria
Wathsala Wijayalath,Sai Majji,Eileen Villasante,Teodor D. Brumeanu,Thomas L. Richie,Sofia Casares,Sofia Casares +6 more
TL;DR: DRAG mice represent the first human-immune-system humanized mouse model that sustains the complex vertebrate life cycle of P. falciparum parasites and may help deciphering immune correlates of protection and to identify protective malaria antigens.
Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice
Sai Majji,Wathsala Wijayalath,Soumya Shashikumar,Luis Pow-Sang,Eileen Villasante,Teodor D. Brumeanu,Sofia Casares,Sofia Casares +7 more
TL;DR: The results indicated a multifactorial effect of the HLA-DR4 transgene on development and function of human CD4 T cells, antigen-specific human CD8 T Cells, and immunoglobulin class switching.
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Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults
Dorothy Anum,Dorothy Anum,Kwadwo A. Kusi,Harini Ganeshan,Michael R. Hollingdale,Michael F. Ofori,Kwadwo A. Koram,Ben Gyan,Susan Adu-Amankwah,Edem Badji,Jun Huang,Maria Belmonte,Glenna Banania,Theophilus B Kwofie,Eileen Villasante,Daniel Dodoo,Martha Sedegah +16 more
TL;DR: Results suggest natural malaria transmission induces CelTOS-specific ex vivo IFN-γ in Ghanaian adults and that the frequency of these responses was similar to those of other previously characterized malaria antigens, which support the further evaluation of CelT OS as a pre-erythrocytic candidate antigen for inclusion in a potential multi-antigen vaccine.
New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model.
Keith Limbach,Keith Limbach,Maureen E. Stefaniak,Maureen E. Stefaniak,Ping Chen,Noelle B. Patterson,Noelle B. Patterson,Grant Liao,Shaojie Weng,Svetlana Krepkiy,Greg Ekberg,Holly Torano,Damodar Ettyreddy,Kalpana Gowda,Sharvari Sonawane,Sharvari Sonawane,Arnel Belmonte,Arnel Belmonte,Esteban Abot,Esteban Abot,Martha Sedegah,Michael R. Hollingdale,Michael R. Hollingdale,Ann M. Moormann,John M. Vulule,Eileen Villasante,Thomas L. Richie,Douglas E. Brough,Joseph T. Bruder +28 more
TL;DR: The evaluation of the seroprevalence, immunogenicity and efficacy of three newly identified gorilla adenoviruses, GC44, GC45 and GC46, as potential malaria vaccine vectors suggest that these gorilla-based adenovectors have key performance characteristics for an effective malaria vaccine.