Eiko Gotoh
Osaka University
2 Papers
Eiko Gotoh is an academic researcher from Osaka University. The author has contributed to research in topics: Histone methyltransferase & Histone H3. The author has an hindex of 2, co-authored 2 publications.
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Papers
Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Keisuke Tachibana,Eiko Gotoh,Natsuko Kawamata,Kenji Ishimoto,Yoshie Uchihara,Hiroko Iwanari,Akira Sugiyama,Takeshi Kawamura,Yasuhiro Mochizuki,Toshiya Tanaka,Juro Sakai,Takao Hamakubo,Tatsuhiko Kodama,Takefumi Doi +13 more
TL;DR: It is suggested that hSETDB1, localized in the nucleus, might undergo degradation by the proteasome and be exported to the cytosol, resulting in its detection mainly in the cytOSol.
Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.
Kenji Ishimoto,Natsuko Kawamata,Yoshie Uchihara,Moeka Okubo,Reiko Fujimoto,Eiko Gotoh,Keisuke Kakinouchi,Eiichi Mizohata,Nobumasa Hino,Yoshiaki Okada,Yasuhiro Mochizuki,Toshiya Tanaka,Takao Hamakubo,Juro Sakai,Tatsuhiko Kodama,Tsuyoshi Inoue,Keisuke Tachibana,Takefumi Doi +17 more
TL;DR: The results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.