Efrat Wertheimer
Tel Aviv University
25 Papers
321 Citations
Efrat Wertheimer is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Insulin receptor & Insulin. The author has an hindex of 19, co-authored 25 publications. Previous affiliations of Efrat Wertheimer include National Institutes of Health.
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Papers
Mutations in the insulin receptor gene.
Simeon I. Taylor,Alessandro Cama,Domenico Accili,Fabrizio Barbetti,Michael J. Quon,Maria de la Luz Sierra,Yoshifumi Suzuki,Elizabeth Roller,Rachel Levy-Toledano,Efrat Wertheimer,Victoria Y. Moncadaj,Hiroko Kadowaki,Takashi Kadowaki +12 more
TL;DR: This review describes mutations in the insulin receptor gene that have been identified in patients with genetic forms of insulin resistance and indicates that identification of these mutations has elucidated the molecular mechanisms that cause disease in these patients.
316
Glucose Effects on Skin Keratinocytes: Implications for Diabetes Skin Complications
Natalia Spravchikov,Galina Sizyakov,Marina Gartsbein,Domenico Accili,Tamar Tennenbaum,Efrat Wertheimer +5 more
TL;DR: The results demonstrate that hyperglycemia and impaired insulin signaling might be directly involved in the development of chronic complications of diabetes by impairing glucose utilization of skin keratinocytes as well as skin proliferation and differentiation.
245
Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins
TL;DR: A series of the synthetic protein tyrosine kinase inhibitors known as tyrphostins were studied for their effect on insulin-like growth factor-1 and insulin-stimulated cellular proliferation on NIH-3T3 fibroblasts overexpressing either receptor, as well as for their ability to inhibit ligand- Stimulated receptor autophosphorylation and tyrosin kinase activity toward exogenous substrates.
218
Insulin-Like Growth Factor 1 Receptor Signaling Regulates Skin Development and Inhibits Skin Keratinocyte Differentiation
Marianna Sadagurski,Shoshana Yakar,Galina Weingarten,Martin Holzenberger,Christopher J. Rhodes,Dirk Breitkreutz,Derek LeRoith,Efrat Wertheimer +7 more
TL;DR: It is demonstrated that IGF-1R-deficient skin cocultures show abnormal maturation and differentiation patterns and that mammalian target of rapamycin plays a specific role in mediating IGF- 1R impedance of action on keratinocyte differentiation.
142
Homozygous deletion of the human insulin receptor gene results in leprechaunism
TL;DR: This investigation has identified a one year–old boy from a consanguineous pedigree who is homozygous for deletion of the insulin receptor gene resulting in leprechaunism.
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