Edwin Murungi
Egerton University
16 Papers
64 Citations
Edwin Murungi is an academic researcher from Egerton University. The author has contributed to research in topics: Biology & Trypanosoma brucei. The author has an hindex of 6, co-authored 16 publications. Previous affiliations of Edwin Murungi include South African National Bioinformatics Institute.
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Papers
Genome-Wide Comparative Analysis of Chemosensory Gene Families in Five Tsetse Fly Species.
Rosaline W. Macharia,Rosaline W. Macharia,Paul O. Mireji,Edwin Murungi,Grace Murilla,Alan Christoffels,Serap Aksoy,Daniel K. Masiga +7 more
TL;DR: This work identified and annotated the major chemosensory gene families in Glossina and identified, in all species, homologs of Ir84a; a Drosophila-specific ionotropic receptor that promotes male courtship suggesting that this is a conserved trait in tsetse flies.
Resistance related metabolic pathways for drug target identification in Mycobacterium tuberculosis
TL;DR: Ten compounds identified in this study should be considered for experimental studies to validate their potential as inhibitors of Rv1712, one of the putative drug targets.
A comparative analysis of trypanosomatid SNARE proteins
Edwin Murungi,Lael D. Barlow,Divya Venkatesh,Vincent O. Adung'a,Joel B. Dacks,Mark C. Field,Alan Christoffels +6 more
TL;DR: Despite highly distinct life styles, the complement oftrypanosomatid SNAREs is quite stable between the three pathogenic lineages, suggesting establishment in the last common ancestor of trypanosomes and Leishmania.
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A proteomics approach reveals molecular manipulators of distinct cellular processes in the salivary glands of Glossina m. morsitans in response to Trypanosoma b. brucei infections
TL;DR: The data implicate the significantly upregulated proteins as manipulators of diverse cellular processes in response to T. brucei infection, potentially to prepare the MT-parasites for invasion and evasion of the mammalian host immune defences.
Comparative Analysis of Salivary Gland Proteomes of Two Glossina Species that Exhibit Differential Hytrosavirus Pathologies.
Henry M. Kariithi,Henry M. Kariithi,Henry M. Kariithi,İkbal Agah İnce,Sjef Boeren,Edwin Murungi,Irene K. Meki,Irene K. Meki,Everlyne A. Otieno,Steven G. Nyanjom,Monique M. van Oers,Just M. Vlak,Adly M. M. Abd-Alla +12 more
TL;DR: In this paper, the authors used mass spectrometry to study SG proteomes of Glossina pallidipes and G. morsitans, two Glossina model species that exhibit differential GpSGHV pathologies (high and low incidence of SGH, respectively).