Edward K. Wakeland
University of Texas Southwestern Medical Center
275 Papers
3.3K Citations
Edward K. Wakeland is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Lupus erythematosus & Gene. The author has an hindex of 74, co-authored 265 publications. Previous affiliations of Edward K. Wakeland include University of Texas at Dallas & Stanford University.
Chat about Author
Papers
Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus.
TL;DR: Clinical strains of RSV differ in cytokine/chemokine induction and in induction and suppression of host genes expression suggesting that these viruses may have inherent differences in virulence potential.
Systemic IFN-α drives kidney nephritis in B6.Sle123 mice
Anna-Marie Fairhurst,Alexis Mathian,John E. Connolly,Andrew Wang,Hillery Fields Gray,Tiffany A. George,Christopher Boudreaux,Xin J. Zhou,Quan Zhen Li,Sophie Koutouzov,Jacques Banchereau,Edward K. Wakeland +11 more
TL;DR: The predominant impact of systemic IFN‐α in this murine model is an exacerbation of mechanisms mediating end organ damage, resulting in severe glomerulonephritis in B6.Sle123 mice.
•Journal Article
Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.
TL;DR: Sle2 harbors a gene that leads to B cell hyperactivity and elevated B1 cell formation, however, Sle2 by itself on the normal B6 background is insufficient to generate IgG antinuclear Abs (ANA) or nephritis.
The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells
TL;DR: These experiments showed that Sle1 expression results in both B and T cells intrinsic defects and demonstrate that the documented involvement of each cell compartment in the production of anti-chromatin Abs corresponds to genetic defects rather than bystander effects.
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study
Christopher J. Lessard,Christopher J. Lessard,Christopher J. Lessard,Indra Adrianto,John A. Ice,Graham B. Wiley,Jennifer A. Kelly,Stuart B. Glenn,Adam Adler,He Li,He Li,Astrid Rasmussen,Adrienne H. Williams,Julie T. Ziegler,Mary E. Comeau,Miranda C. Marion,Benjamin E. Wakeland,Chaoying Liang,Paula S. Ramos,Kiely Grundahl,Caroline J. Gallant,Graciela S. Alarcón,Juan-Manuel Anaya,Sang Cheol Bae,Susan A. Boackle,Elizabeth E. Brown,Deh Ming Chang,Soo-Kyung Cho,Lindsey A. Criswell,Jeffrey C. Edberg,Barry I. Freedman,Gary S. Gilkeson,Chaim O. Jacob,Judith A. James,Judith A. James,Diane L. Kamen,Robert P. Kimberly,Jae Hoon Kim,Javier Martin,Joan T. Merrill,Timothy B. Niewold,So-Yeon Park,Michelle Petri,Bernardo A. Pons-Estel,Rosalind Ramsey-Goldman,John D. Reveille,R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Yeong Wook Song,Anne M. Stevens,Anne M. Stevens,Betty P. Tsao,Luis M. Vilá,Timothy J. Vyse,Chack-Yung Yu,Chack-Yung Yu,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Kenneth M. Kaufman,John B. Harley,John B. Harley,Edward K. Wakeland,Carl D. Langefeld,Patrick M. Gaffney,Patrick M. Gaffney,Courtney G. Montgomery,Kathy L. Moser,Kathy L. Moser +69 more
TL;DR: The results of this study increase the number of confirmed SLE risk loci and identify others warranting further investigation, as well as identifying several genes relevant to immunological pathways showed association with SLE.