Edward J. Fitzsimons
University of Glasgow
19 Papers
303 Citations
Edward J. Fitzsimons is an academic researcher from University of Glasgow. The author has contributed to research in topics: ALAS2 & Protoporphyrin IX. The author has an hindex of 11, co-authored 18 publications. Previous affiliations of Edward J. Fitzsimons include Western Infirmary.
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Papers
Four new mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causing X-linked sideroblastic anemia: increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary hemochromatosis.
Philip D. Cotter,Alison May,Liping Li,A. I. Al-Sabah,Edward J. Fitzsimons,Mario Cazzola,David F. Bishop +6 more
TL;DR: The value of combined phlebotomy and pyridoxine supplementation in the management of XLSA probands is indicated in order to prevent a downward spiral of iron toxicity and refractory anemia.
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6 Sideroblastic anaemia
Alison May,Edward J. Fitzsimons +1 more
TL;DR: In this article, the cause of sideroblastic anaemia has been investigated in a large number of families with known cases of congenital sideroblastoma and careful documentation of the clinical outcome of these cases and of other family members is invaluable.
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Severe vincristine toxicity in combination with itraconazole
TL;DR: Two patients with acute lymphoblastic leukaemia who were entered into the current MRC adult ALL trial (UKALL XII) in whom unusually severe vincristine induced neurotoxicity developed appeared to be the result of an interaction with itraconazole suspension.
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Inappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: an unusual and fatal triad in a patient 13 months post Rituximab and autologous stem cell transplantation.
TL;DR: A case of varicella-zoster virus infection associated with severe abdominal pain, inappropriate antidiuretic hormone secretion (SIADH) and death, 13 months post-autologous peripheral blood stem cell transplantation (PBSCT), speculation as to why this occurred is speculated.
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Erythroblast iron metabolism and serum soluble transferrin receptor values in the anemia of rheumatoid arthritis.
Edward J. Fitzsimons,Tracey Houston,Robin Munro,Roger D. Sturrock,Anthony B. J. Speekenbrink,Jeremy H. Brock +5 more
TL;DR: An increase in erythroblast surface TfR efficiency for Tf-iron uptake compensates for the low plasma iron levels associated with anemia in RA and helps to maintain RA ery Throttleblast iron uptake.
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