Edward Hookway
University College London
4 Papers
4 Citations
Edward Hookway is an academic researcher from University College London. The author has contributed to research in topics: Flagellum & Gene silencing. The author has an hindex of 4, co-authored 4 publications.
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Papers
Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections
Tom Beneke,François Demay,Edward Hookway,Nicole Ashman,Heather Jeffery,James R. Smith,Jessica Valli,Tomas Becvar,Jitka Myskova,Tereza Lestinova,Shahaan Shafiq,Shahaan Shafiq,Jovana Sadlova,Petr Volf,Richard J. Wheeler,Eva Gluenz +15 more
TL;DR: Examination of protein composition and in vivo function of the promastigote flagellum in Leishmania sp.
134
Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement.
Fernanda Amary,Luis Perez-Casanova,Hongtao Ye,Lucia Cottone,Anna-Christina Strobl,Paul Cool,Elena Miranda,Fitim Berisha,William Aston,Maia Rocha,Maia Rocha,Paul O'Donnell,Nischalan Pillay,Nischalan Pillay,Roberto Tirabosco,Daniel Baumhoer,Edward Hookway,Adrienne M. Flanagan,Adrienne M. Flanagan +18 more
TL;DR: It is demonstrated that FN1 and/or AVCR2A gene rearrangements do not distinguish between benign and malignant synovial chondromatosis, and differentiating these lesions will potentially alter clinical management by allowing soft tissue chondrosarcoma to be managed more conservatively.
97
Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival
Lucia Cottone,Edward Hookway,Adam P. Cribbs,Graham Wells,Patrick Lombard,Lorena Ligammari,Anthony Tumber,Roberto Tirabosco,Fernanda Amary,T. Szommer,Catrine Johannson,Paul Brennan,Nischalan Pillay,U. Oppermann,Adrienne M. Flanagan +14 more
TL;DR: Previous data showing that the function of TBXT is essential for maintaining notochord cell fate and function are supported and the data suggest that TBXT can potentially be targeted therapeutically by modulating epigenetic control mechanisms such as H3K27 demethylases are suggested.
Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections
Tom Beneke,François Demay,Edward Hookway,Nicole Ashman,Heather Jeffery,James R. Smith,Jessica Valli,Tomas Becvar,Jitka Myskova,Tereza Lestinova,Shahaan Shafiq,Jovana Sadlova,Petr Volf,Richard J. Wheeler,Eva Gluenz +14 more
TL;DR: The data show that L. mexicana need directional motility for successful colonisation of sand flies and that paralysed and uncoordinated Leishmania were rapidly lost from flies.