Edward C. Cox

TL;DR: This work directly demonstrates transcriptional bursting in Escherichia coli, similar to that indirectly inferred for eukaryotes, and extends protein-based approaches by counting the integer-valued number of transcript with single-molecule resolution.

TL;DR: A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.

TL;DR: This work tracks the motion of individual fluorescently labeled mRNA molecules inside live E. coli cells and finds that the motion is subdiffusive, with an exponent that is robust to physiological changes, including the disruption of cytoskeletal elements.

TL;DR: The ability to identify regulatory protein binding sites de novo, determine the sequence-dependent binding energy of the proteins that bind these sites, and, importantly, measure the in vivo interaction energy between RNA polymerase and a DNA-bound transcription factor is demonstrated.