Eduardo Marbán
Cedars-Sinai Medical Center
607 Papers
7.1K Citations
Eduardo Marbán is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Medicine & Heart failure. The author has an hindex of 129, co-authored 579 publications. Previous affiliations of Eduardo Marbán include Yale University & Pasteur Institute.
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Papers
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
Dan E. Arking,M. Juhani Junttila,M. Juhani Junttila,Philippe Goyette,Adriana Huertas-Vazquez,Mark Eijgelsheim,Marieke T. Blom,Christopher Newton-Cheh,Christopher Newton-Cheh,Kyndaron Reinier,Carmen Teodorescu,Audrey Uy-Evanado,Naima Carter-Monroe,Kari S. Kaikkonen,Marja-Leena Kortelainen,Gabrielle Boucher,Caroline Lagacé,Anna Moes,Xiaoqing Zhao,Frank D. Kolodgie,Fernando Rivadeneira,Albert Hofman,Jacqueline C.M. Witteman,André G. Uitterlinden,Roos F. Marsman,Raha Pazoki,Abdennasser Bardai,Rudolph W. Koster,Abbas Dehghan,Shih-Jen Hwang,Pallav Bhatnagar,Wendy S. Post,Gina Hilton,Ronald J. Prineas,Man Li,Anna Köttgen,Georg Ehret,Georg Ehret,Eric Boerwinkle,Josef Coresh,W. H. Linda Kao,Bruce M. Psaty,Bruce M. Psaty,Gordon F. Tomaselli,Nona Sotoodehnia,David S. Siscovick,Greg L. Burke,Eduardo Marbán,Peter M. Spooner,L. Adrienne Cupples,L. Adrienne Cupples,Jonathan Jui,Karen Gunson,Y. Antero Kesäniemi,Arthur A.M. Wilde,Jean-Claude Tardif,Christopher J. O'Donnell,Connie R. Bezzina,Renu Virmani,Bruno H. Stricker,Hanno L. Tan,Christine M. Albert,Aravinda Chakravarti,John D. Rioux,Heikki V. Huikuri,Sumeet S. Chugh +65 more
TL;DR: A genome-wide association meta-analysis is performed in 1,283 SCD cases and >20,000 control individuals of European ancestry to identify the BAZ2B locus as associated with SCD and test the role of 49 SNPs previously implicated in modulating electrocardiographic traits (QRS, QT, and RR intervals).
Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle.
TL;DR: The finding of enhanced susceptibility to calcium overload helps to rationalize the functional deterioration of stunned myocardium during intense inotropic stimulation and additionally suggests that stunnedMyocardium may represent a favorable substrate for triggered arrhythmias.
Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.
TL;DR: These residues do not act solely by electrostatic attraction of permeant ions, but instead may help to form ion‐specific binding sites within the pore, necessitating revision of prevailing concepts regarding the role of superficial negatively charged residues in the process of ion permeation.
Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.
Jeffrey R. Balser,H B Nuss,D W Orias,David C. Johns,Eduardo Marbán,Gordon F. Tomaselli,John H. Lawrence +6 more
TL;DR: The results support a reinterpretation of local anesthetic action whereby lidocaine functions as an allosteric effector to enhance Na channel inactivation.
Structure of the sodium channel pore revealed by serial cysteine mutagenesis
M. T. Pérez-García,Nipavan Chiamvimonvat,Eduardo Marbán,Gordon F. Tomaselli,Gordon F. Tomaselli +4 more
TL;DR: Serial cysteine mutagenesis reveals a pattern of side-chain accessibility that contradicts currently favored structural models based on alpha-helices or beta-strands.