Edith Cheng
University of Toronto
5 Papers
28 Citations
Edith Cheng is an academic researcher from University of Toronto. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 2 publications.
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Papers
Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer
Christine M. Misquitta-Ali,Edith Cheng,Dave O'Hanlon,Ni Liu,C. Jane McGlade,Ming-Sound Tsao,Benjamin J. Blencowe +6 more
TL;DR: Widespread AS changes in NSCLC that impact cell signaling in a manner that likely contributes to tumorigenesis are revealed.
159
Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins in Saccharomyces cerevisiae
Edith Cheng,Jessica A. Vaisica,Jiongwen Ou,Anastasia Baryshnikova,Yong Lu,Frederick P. Roth,Frederick P. Roth,Grant W. Brown +7 more
TL;DR: A core set of 15 genes involved in DNA replication that are critical in preventing both spontaneous DNA damage and genome rearrangements are identified and a mechanisms by which depletion of essential replication proteins can lead to double-stranded DNA breaks near these features are proposed.
28
Rare schizophrenia risk variant burden is conserved in diverse human populations
Yongmei Liu,D. Meyer,B. V. Fennessy,Can Feng,Edith Cheng,Marysia-Kolbe Rieder,S. Ascolillo,A. de Pins,Amanda Dobbyn,D. Lebovitch,Elisa L. J. Moya,Tham Nguyen,Leon Wilkins,Annum Hassan,Schizophrenia Exome Meta-analysis Consortium,Katherine E. Burdick,J. Buxbaum,Enrico Domenici,S Frangou,T. Hartmann,Dheeraj Malhotra,Carlos N. Pato,Michele T. Pato,K. Ressler,Panagiotis Roussos,Dan Rujescu,Claudia Monsalve Arango,A. Bertolino,Giuseppe Blasi,Luisella Bocchio-Chiavetto,Dominique Campion,V. Carr,Janice M. Fullerton +32 more
TL;DR: A custom sequencing panel based on current knowledge of the genetic architecture of schizophrenia was designed and applied to a new cohort of 22,135 individuals of diverse ancestries, lending robust support to the rare allelic spectrum of the Genetic Architecture of schizophrenia being conserved across diverse human populations.
5
African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison Across Women of African Descent
Rachel Martini,P. Delpe,Timothy Chu,K. Arora,B. Lord,Ankur Verma,Y. Chen,Endale Hadgu Gebregzabher,Joseph K. Oppong,Ernest Adjei,Aisha Jibril,Baffour Awuah,Mulusew Bekele,Edgeit Abebe,Ishmael Kyei,Frances S. Aitpillah,Michael O. Adinku,Kwasi Ankomah,Ernest Osei-Bonsu,Dhananjay Chitale,Jessica Bensenhaver,S. David Nathanson,Latoya Jackson,Evelyn Jiagge,Lindsay Petersen,Erica Proctor,Kofi Gyan,Lee D. Gibbs,Z. Monojlovic,Rick A. Kittles,Jerome White,Clayton Yates,Upender Manne,Kathleen Gardner,Nigel P. Mongan,Edith Cheng,Paula S. Ginter,Shams Hoda,Olivier Elemento,Nicolas Robine,Andrea Sboner,John D. Carpten,Leslie C. Newman,M. B. Davis +43 more
TL;DR: Using genetic ancestry estimation in this African-enriched cohort of AAs, west and east Africans with TNBC, RNAseq revealed tumor-associated immune cell infiltration and activity and identified 613 genes associated with African ancestry and more than 2200 gene associated with regional-level African ancestry.
LSD1 is required for euchromatic origin firing and replication timing
Yuejiao Wang,Yunchao Huang,Edith Cheng,Xinhua Liu,Jianguo Yang,Jordan T.F. Young,Grant W. Brown,Xiaohan Yang,Yongfeng Shang +8 more
TL;DR: In this article , the authors show that LSD-engaged DNA replication is mechanistically linked to the loading of TopBP1-Interacting Checkpoint and Replication Regulator (TICRR) onto the pre-RC and subsequent recruitment of CDC45 during origin firing.