Edit Tarcsa
National Institutes of Health
10 Papers
318 Citations
Edit Tarcsa is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Loricrin & Trichohyalin. The author has an hindex of 8, co-authored 8 publications.
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Papers
Protein Unfolding by Peptidylarginine Deiminase SUBSTRATE SPECIFICITY AND STRUCTURAL RELATIONSHIPS OF THE NATURAL SUBSTRATES TRICHOHYALIN AND FILAGGRIN
TL;DR: Data suggest that the ureido group on the citrulline formed by the peptidylarginine deiminase enzyme modification functions to unfold proteins due to decrease in net charge, loss of potential ionic bonds, and interference with H bonds.
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Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein
Eleonora Candi,Gerry Melino,Giampiero Mei,Edit Tarcsa,Soo-Il Chung,Lyuben N. Marekov,Peter M. Steinert +6 more
TL;DR: The data support a hypothesis for the essential and complementary roles of both TGase 1 and TGase 3 in cross-linking of loricrin in vivo, and may explain the phenotype of lamellar ichthyosis, a disease caused by mutations in theTGase 1 gene.
173
The Fate of Trichohyalin SEQUENTIAL POST-TRANSLATIONAL MODIFICATIONS BY PEPTIDYL-ARGININE DEIMINASE AND TRANSGLUTAMINASES
Edit Tarcsa,Lyuben N. Marekov,Jeanne M. Andreoli,William W. Idler,Eleonora Candi,Soo-Il Chung,Peter M. Steinert +6 more
TL;DR: In vitro data suggest an in vivo model in which THH located in insoluble cytoplasmic droplets is first modified by peptidyl-arginine deiminase which denatures it and makes it more soluble, and renders it available for efficient cross-linking by TGase 3 to form highly cross-linked rigid structures in the cells.
154
A Highly Conserved Lysine Residue on the Head Domain of Type II Keratins is Essential for the Attachment of Keratin Intermediate Filaments to the Cornified cell Envelope through Isopeptide Crosslinking by Transglutaminases
Eleonora Candi,Edit Tarcsa,John J. DiGiovanna,John G. Compton,Peter M. Elias,Lyuben N. Marekov,Peter M. Steinert +6 more
TL;DR: Together, these data suggest a mechanism for the coordination of cornified cell structure by permanent covalent attachment of the keratin intermediate filament cytoskeleton to the cell envelope by transglutaminase crosslinking.
117
Transglutaminase Cross-linking Properties of the Small Proline-rich 1 Family of Cornified Cell Envelope Proteins INTEGRATION WITH LORICRIN
Eleonora Candi,Edit Tarcsa,William W. Idler,Tonja Kartasova,Lyuben N. Marekov,Peter M. Steinert +5 more
TL;DR: It is proposed that TGase 3 first cross-links loricrin and SPRs together to form small interchain oligomers, which are then permanently affixed to the developing CE by further cross-linking by the TGase 1 enzyme.
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