Edgar Schuck
Eisai
37 Papers
104 Citations
Edgar Schuck is an academic researcher from Eisai. The author has contributed to research in topics: Pharmacokinetics & Eribulin Mesylate. The author has an hindex of 13, co-authored 34 publications.
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Papers
Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.
Mohamad Shebley,Punam Sandhu,Arian Emami Riedmaier,Masoud Jamei,Rangaraj Narayanan,Aarti Patel,Sheila Annie Peters,Venkatesh Pilla Reddy,Ming Zheng,Loeckie de Zwart,Maud Beneton,Francois Bouzom,Jun Chen,Yuan Chen,Yumi Cleary,Christiane Collins,Gemma L. Dickinson,Nassim Djebli,Heidi J. Einolf,Iain Gardner,Felix Huth,Faraz Kazmi,Feras Khalil,Jing Lin,Aleksandrs Odinecs,Chirag Patel,Haojing Rong,Edgar Schuck,Pradeep Sharma,Shu Pei Wu,Yang Xu,Shinji Yamazaki,Kenta Yoshida,Malcolm Rowland +33 more
TL;DR: This work provides a perspective on the qualification and verification of physiologically based pharmacokinetic (PBPK) platforms/models intended for regulatory submission based on the collective experience of the Simcyp Consortium members.
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New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial
Faustino Torrico,Joaquim Gascon,Fabiana Barreira,Bethania Blum,Igor C. Almeida,Cristina Alonso-Vega,Tayná Barboza,Graeme Bilbe,Erika Correia,Wilson Garcia,Lourdes Ortiz,Rudy Parrado,Juan Carlos Ramirez,Isabela Ribeiro,Nathalie Strub-Wourgaft,Michel Vaillant,Sergio Sosa-Estani,Roger Arteaga,Anabelle de la Barra,Jhonny Camacho Borja,Ivana Martinez,Jayme Fernandes,Lineth Garcia,Daniel Lozano,Alejandro Palacios,Alejandro G. Schijman,María-Jesús Pinazo,Jimmy Pinto,Gimena Rojas,Igor Estevao,Uriel Ortega-Rodriguez,Maria Tays Mendes,Edgar Schuck,Katsura Hata,Noritsugu Maki,Makoto Asada +35 more
TL;DR: A double-blind, double-dummy, phase 2, multicentre, randomised trial in three outpatient units in Bolivia as mentioned in this paper was conducted to evaluate the efficacy and safety of new benznidazole monotherapy regimens and combinations with fosravuconazole, in the treatment of Chagas disease.
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Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Marjoleen Nijsen,Fan Wu,Loveleena Bansal,Erica L. Bradshaw-Pierce,Jason R. Chan,Bianca M. Liederer,Jerome T. Mettetal,Patricia Schroeder,Edgar Schuck,Alice Tsai,Christine Xu,Anjaneya Chimalakonda,Kha Le,Mark Penney,Brian Topp,Akihiro Yamada,Mary E. Spilker +16 more
- 01 Mar 2018
TL;DR: The survey results provide insights on the current state of preclinical QSP modeling in addition to future opportunities, and call attention to the need for an aligned definition and consistent terminology around QSP.
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Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.
Erica L. Bradshaw,Mary E. Spilker,Richard Zang,Loveleena Bansal,Handan He,Rhys D.O. Jones,Kha Le,Mark Penney,Edgar Schuck,Brian Topp,Alice Tsai,Christine Xu,Marjoleen Nijsen,Jason R. Chan +13 more
- 01 Nov 2019
TL;DR: Quantitative systems pharmacology approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline.
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Design, Synthesis, and Pharmacological Evaluation of Fluorinated Tetrahydrouridine Derivatives as Inhibitors of Cytidine Deaminase
Dana Ferraris,Bridget Duvall,Bridget Duvall,Greg Delahanty,Greg Delahanty,Bipin Mistry,Jesse Alt,Jesse Alt,Camilo Rojas,Camilo Rojas,Christopher Rowbottom,Kristen Sanders,Edgar Schuck,Kuan-Chun Huang,Sanjeev Redkar,Barbara Slusher,Barbara Slusher,Takashi Tsukamoto,Takashi Tsukamoto +18 more
TL;DR: It is demonstrated that compound 7a can serve as an acid-stable alternative to 5 as a pharmacoenhancer of drugs subject to CDA-mediated metabolism.
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