Edgar E. Kooijman
Kent State University
61 Papers
674 Citations
Edgar E. Kooijman is an academic researcher from Kent State University. The author has contributed to research in topics: Phosphatidic acid & Chemistry. The author has an hindex of 24, co-authored 54 publications. Previous affiliations of Edgar E. Kooijman include Argonne National Laboratory & Tel Aviv University.
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Papers
Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid
TL;DR: The hypothesis that a conversion of lysophosphatidic acid into phosphatidIC acid by endophilin or BARS may induce negative spontaneous monolayer curvature and regulate endocytic and Golgi membrane fission is supported.
399
Spontaneous Curvature of Phosphatidic Acid and Lysophosphatidic Acid
Edgar E. Kooijman,Vladimir Chupin,N. L. Fuller,Michael M. Kozlov,Ben de Kruijff,Koert N.J. Burger,Peter R. Rand +6 more
TL;DR: The spontaneous radius of curvature (R(0p)) of PA and LPA, carrying oleoyl fatty acids, is determined using well-established X-ray diffraction methods and finds that PA has considerable negative spontaneous curvature while LPA has the most positive spontaneous curvatures of any membrane lipid measured to date.
What Makes the Bioactive Lipids Phosphatidic Acid and Lysophosphatidic Acid So Special
Edgar E. Kooijman,Karen M. Carter,Emma G. van Laar,Vladimir Chupin,Koert N.J. Burger,Ben de Kruijff +5 more
TL;DR: The findings can be understood in terms of a hydrogen bond formed within the phosphomonoester headgroup of (L)PA and its destabilization by competing intra- or intermolecular hydrogen bonds.
Biophysics and function of phosphatidic acid: A molecular perspective
TL;DR: This work will take a molecular approach focusing entirely on the physical chemistry of the lipid and develop a model explaining the ionization properties of phosphatidic acid, termed the electrostatic-hydrogen bond switch model.
156
Drug Resistance in Breast Cancer Cells: Biophysical Characterization of and Doxorubicin Interactions with Membrane Lipids
Chiranjeevi Peetla,Radhika Bhave,Sivakumar Vijayaraghavalu,Andrew Stine,Edgar E. Kooijman,Vinod Labhasetwar +5 more
TL;DR: Biophysical properties of resistant cell membrane lipids significantly influence drug transport, and hence drug efficacy, in breast cancer cells, and lipid-doxorubicin interactions appear to decrease intracellular drug transport via diffusion as the drug is trapped in the lipid bilayer.