Eckhard Weber
Novartis
15 Papers
50 Citations
Eckhard Weber is an academic researcher from Novartis. The author has contributed to research in topics: Medicine & Self-healing hydrogels. The author has an hindex of 4, co-authored 9 publications.
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Papers
Large-scale prediction and testing of drug activity on side-effect targets
Eugen Lounkine,Michael J. Keiser,Steven Whitebread,Dmitri Mikhailov,Jacques Hamon,Jeremy L. Jenkins,Paul Lavan,Eckhard Weber,Allison K. Doak,Serge Côté,Brian K. Shoichet,Laszlo Urban +11 more
TL;DR: An association metric is developed to prioritize those new off-targets that explained side effects better than any known target of a given drug, creating a drug–target–adverse drug reaction network and may have wide application to de-risking toxicological liabilities in drug discovery.
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
Eckhard Weber,Ammar Haouimi +1 more
TL;DR: In this paper , a hydrogel serving as a high capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J m−2) to tendon on opposite surfaces of the hydrogels, as they show with porcine and human tendon preparations during cyclic-friction loadings.
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Noninvasive assessment of gastric emptying by near-infrared fluorescence reflectance imaging in mice: pharmacological validation with tegaserod, cisapride, and clonidine.
Hans-Ulrich Gremlich,Vicente Martínez,Rainer Kneuer,Willy Kinzy,Eckhard Weber,Hans-Juergen Pfannkuche,Markus Rudin +6 more
TL;DR: FRI using fluorescently labeled beads allows the reliable determination of gastric emptying as well as the assessment of pharmacological interventions and offers the potential to characterize molecular targets and pathways involved in physiological regulation and pharmacological modulation of gastrics emptying.
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Relationship between tendon structure, stiffness, gait patterns and patient reported outcomes during the early stages of recovery after an Achilles tendon rupture.
Didier Laurent,Lorcan Walsh,Amir Muaremi,Nicolau Beckmann,Eckhard Weber,Frederique Chaperon,H. Haber,Joerg Goldhahn,Andrea Klauser,Michael Blauth,Matthias Schieker +10 more
TL;DR: Significant correlations found between tendon stiffness, insole variables and distinct ATRS activities, suggest clinical relevance of tendon stiffness and foot plantar pressure measurements and illustrate how digital biomarkers can track recovery in function over time.
1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats.
TL;DR: Careful selection of administration routes is recommended for ABT use in vivo, variable oral absorption of coadministered compounds can be expected due to a disturbance of gastrointestinal transit, and extensive variability in plasma-concentration time profiles was apparent.
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