Ebbe Boedtkjer
Aarhus University
68 Papers
116 Citations
Ebbe Boedtkjer is an academic researcher from Aarhus University. The author has contributed to research in topics: Intracellular pH & Cancer. The author has an hindex of 23, co-authored 51 publications.
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Papers
The Acidic Tumor Microenvironment as a Driver of Cancer.
Ebbe Boedtkjer,Stine F. Pedersen +1 more
TL;DR: This review discusses how the acidity of the tumor microenvironment influences each stage in cancer development, from dysplasia to full-blown metastatic disease, and how the compartmentalized pH microenvironment favors cancer development.
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Disruption of Na+,HCO3− Cotransporter NBCn1 (slc4a7) Inhibits NO-Mediated Vasorelaxation, Smooth Muscle Ca2+ Sensitivity, and Hypertension Development in Mice
Ebbe Boedtkjer,Jeppe Praetorius,Vladimir V. Matchkov,Edgaras Stankevičius,Susie Mogensen,Annette Füchtbauer,Ulf Simonsen,Ernst-Martin Füchtbauer,Christian Aalkjaer +8 more
TL;DR: In this article, the authors investigated whether Na+,HCO3− cotransporter NBCn1, by regulating intracellular pH (pHi), influences artery function and blood pressure regulation.
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Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice.
TL;DR: The expression pattern of the electroneutral Na(+)-HCO(3)(-)cotransporter NBCn1 was investigated by beta-galactosidase staining of mice with a LacZ insertion, finding that it has a broad expression profile, supporting previous findings based on immunoreactivity.
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The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms.
Anne Poder Andersen,Jacob Samsøe-Petersen,Eva Kjer Oernbo,Ebbe Boedtkjer,José M.A. Moreira,Marie Kveiborg,Stine F. Pedersen +6 more
TL;DR: Different types of net acid extruding transporters, NHE1, NBCn1 and MCT4, are frequently expressed in patient mammary tumor tissue and it is demonstrated for the first time that they promote growth of TNBC human mammary tumors in vivo via distinct but overlapping mechanisms.
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NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pHi in the vascular wall
TL;DR: It is shown that intracellular acidification alters enzymatic activity and consequently artery dilatation and contraction and the need to evaluate acid–base transport in conditions of vascular disease and blood pressure disturbances is underscored.
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