An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Extended Wear Ophthalmic Lens

A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a bioactive material. The bioactive material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The bioactive material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.

Thromboresistant surface treatment for biomaterials

A process for treating fibers to render the fibers more hydrophilic. The process includes contacting the fibers with a solution of hydrophilic monomers and radical polymerization initiators and exposing the fibers to UV radiation.

Absorbent Articles Comprising Hydrophilic Nonwoven Fabrics

The invention includes a method of coating a substrate, comprising exposing a substrate to an initiator capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate; contacting the substrate with a composition comprising one or more monomers in a medium which has different hydrophilicity compared to the substrate, and grafting monomer molecules onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. With the invention, novel coated articles can be obtained which are particularly useful as medical products such as catheters.

Graft polymerization of substrate surfaces

Disclosed are methods and related compositions for altering the physical and chemical properties of a substrate used in hydrocarbon exploitation, such as in downhole drilling operations. In a preferred embodiment a method involves formulating a fluid, tailored to the specific drilling conditions, that contains one or more inactivated enzymes. Preferably the enzyme is inactivated by encapsulation in a pH responsive material. After the fluid has been introduced into the well bore, one or more triggering signals, such as a change in pH, is applied to the fluid that will activate or reactivate the inactivated enzyme, preferably by causing it to be released by the encapsulation material. The reactivated enzyme is capable of selectively acting upon a substrate located downhole to bring about the desired change in the chemical or physical properties of the substrate.

Method for the triggered release of polymer-degrading agents for oil field use

A process for encapsulating a preformed polymeric substrate comprises peroxidizing and hydroperoxidizing the surface of said preformed substrate using ozone and then carrying out a crosslinked graft copolymerization of selected ethylenically unsaturated monomers both on and surrounding (encapsulating) said substrate. Such encapsulation of substrates provides protective coatings, ablative coatings and, particularly, soft skirts for hard contact lenses.

Process for the encapsulation of preformed substrates by graft copolymerization

A process for modifying the surface characteristics of a preformed polymeric substrate to impart hydrophilicity, hydrophobicity or other desired properties thereto comprises peroxidizing and hydroperoxidizing the surface of said preformed substrate using ozone, directing the subsequent graft polymerization of selected ethylenically unsaturated monomers essentially solely to the surface of said substrate to achieve the desired alteration of substrate surface characteristics while maintaining substrate structural integrity. Substrates so modified are useful in biomedical devices, semipermeable membranes, films, fibers and especially contact lenses.

Process for graft copolymerization on surfaces of preformed substrates to modify surface properties

A method of disinfecting a hydrogen peroxide stable contact lens is provided wherein a contact lens is contacted with a hydrogen peroxide solution in a container and a hydrogen peroxide decomposition means is provided in said container, which means is adapted to permit the contact lens to have a cumulative (% peroxide) (min) exposure from the time said decomposition means contacts said peroxide containing solution, time zero, over a period of no greater than 12 hours of at least 20% peroxide·minute. An apparatus capable of carrying out such method is also provided herein. The hydrogen peroxide decomposition means may be, for example, a prepoisoned catalyst, a catalyst partially enclosed in a tube, a dual catalyst control system or a distributed catalyst control system.

Peroxide disinfection method and devices therefor

Processes of using treatment chambers for separating compounds in an aqueous effluent are disclosed. More particularly, the treatment chambers use ultrasonic energy and an electrode potential to provide efficient and effective removal of compounds from aqueous effluents, such as textile effluents.

Treatment chamber for separating compounds from aqueous effluent

A method of disinfecting a hydrogen peroxide stable material by contacting said material with a hydrogen peroxide containing solution and a hydrogen peroxide decomposition means adapted to permit said material to have a cumulative (% peroxide)·(min) exposure from the time said decomposition means contacts said hydrogen peroxide containing solution over a period not exceeding 12 hours of at least 20% (peroxide)·(min). Also, disclosed are devices and components thereof whereby said method can be achieved.

Peroxide disinfection method

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