For patients with follicular lymphoma (FL) requiring treatment, survival advantages have been shown with the addition of anti-CD20 monoclonal antibodies (mAbs) to conventional chemotherapy regimens versus chemotherapy alone for first-line treatment.1 Rituximab was the first anti-CD20 agent approved for FL treatment, and obinutuzumab is a type II anti-CD20 mAb with a distinct mode of action versus rituximab.2–4 In the phase III GALLIUM trial, obinutuzumab plus chemotherapy demonstrated improved progression-free survival versus rituximab plus chemotherapy in patients with previously untreated, advanced FL.5–7 Obinutuzumab is currently administered by intravenous (IV) infusion over 3–4 hours. Previous studies found rituximab was well tolerated as a shorter 90-minute infusion by patients who did not experience grade ≥3 infusion-related reactions (IRRs) after the first standard-rate infusion.8 A 90-minute short duration infusion (SDI) of obinutuzumab may offer the potential to reduce time and resources required to administer treatment, providing time and cost savings for both patients and healthcare settings. GAZELLE (NCT03817853) was an international, open-label, multicenter, single-arm, phase IV study investigating the safety and efficacy of a 90-minute SDI of obinutuzumab as induction (with chemotherapy) and maintenance (as monotherapy) in patients with previously untreated, advanced FL. Here, we report the primary results from GAZELLE, focusing on the induction phase of treatment. All enrolled patients had histologically documented CD20+ FL (grade 1–3a), Eastern Cooperative Oncology Group performance status 0–2, and advanced disease (stage III or IV, or stage II with bulky disease). During the induction phase, IV obinutuzumab (1000 mg) was administered on days (D) 1, 8, and 15 of cycle (C) 1, and on D1 thereafter, plus chemotherapy selected by the investigator for 6–8 cycles (bendamustine; cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP]; or cyclophosphamide, vincristine, and prednisone [CVP]; Suppl. Methods). Obinutuzumab was administered at the standard infusion rate in C1. Patients without a grade ≥3 IRR in C1 received obinutuzumab as a 90-minute SDI (or <110 min) from C2 onwards (including in the maintenance phase). IRRs were defined as any events that occurred during or within 24 hours from the end of study treatment infusion and were judged by an investigator as related to the infusion of study treatment components. Patients with grade ≥3 IRR in C1 received obinutuzumab at the standard infusion rate in C2, and obinutuzumab SDI from C3 onwards if no grade ≥3 IRRs occurred in C2. Patients with a second grade ≥3 IRR or a grade 4 IRR (regardless of infusion rate) discontinued obinutuzumab. The primary end point was the incidence of grade ≥3 IRRs during C2 (severity determined according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0). Secondary safety end points included the incidence, nature, and severity of all-causality adverse events (AEs), and the incidence, timing, and duration of IRRs (any grade). Investigator-assessed objective response rate (ORR) at the end of induction (EOI) according to the site-specific guidelines9–11 was a key secondary end point. Patient-reported outcomes (MD Anderson Symptom Inventory [MDASI] scores12) and provider-reported outcomes were exploratory end points. For data sharing information, see Suppl. Methods. At data cutoff (December 3, 2020), 114 patients were enrolled from 32 centers across 7 countries. A total of 113 patients started induction therapy and comprised the overall population. Fourteen patients from this population were subsequently excluded, leaving 99 patients in the SDI population (Suppl. Figure S1). Baseline patient and disease characteristics are summarized in Suppl. Table S1. Obinutuzumab-bendamustine (45.1% of patients) was the most common treatment regimen, followed by obinutuzumab-CHOP (38.1%); 16.8% of patients received obinutuzumab-CVP. During the induction phase, the overall median cumulative obinutuzumab dose was 8000 mg (range, 80–10,000 mg). At C1D1 and C1D8, the proportion of patients with low obinutuzumab dose intensity (<90%) was 2.7% and 1.8%, respectively (no low dose intensity occurred after C1D8). During the induction phase, 46 patients (40.7%) had ≥1 obinutuzumab infusion modification (Suppl. Table S2). Most infusion modifications were reported during C1 and due to AEs. Infusion interruption was the most common modification. For details of premedication administration and chemotherapy exposure, see Suppl. Results. The median obinutuzumab SDI duration in each cycle of C2–C8 was 95.0–98.0 minutes (Figure 1). Obinutuzumab infusion duration during this part of the induction period was ≤110 minutes in >90% of patients.Figure 1.: Median duration of obinutuzumab infusion by cycle during induction (overall population). aCycles 7 and 8 only included patients who received CVP. C = cycle; CVP = cyclophosphamide, vincristine, and prednisone; D = day; SDI = short duration infusion.Almost all patients (99.1%) experienced AEs of any grade (all causality) during the induction period (Suppl. Table S3). Grade ≥3 AEs and serious AEs (SAEs) were reported in 69.0% and 18.6% of patients, respectively. The most common grade ≥3 AEs were neutropenia (49.6%), leukopenia (11.5%), and lymphopenia (10.6%); SAEs experienced by ≥2 patients were febrile neutropenia (4.4%), pneumonia (2.7%), and neutropenia (1.8%). Infections and infestations were reported for 45 of 113 patients (39.8%; 64 events), with grade ≥3 infections or infestations reported for 10 of 113 patients (8.8%; 14 events). No patients experienced a grade ≥3 IRR with obinutuzumab SDI in C2 (primary end point; Figure 2). IRRs were reported in 71 of 113 patients (62.8%), with most occurring on C1D1. Grade 3 IRRs were reported in 7 of 113 patients (6.2%) during the study; no grade 4 or grade 5 IRRs were reported. Of the 99 patients in the SDI population who received obinutuzumab SDI in C2, 10 (10.1%) experienced an IRR (grade 1, 8.1%; grade 2, 2.0%). In subsequent cycles, only 1 patient experienced a grade ≥3 IRR with obinutuzumab SDI (grade 3 hypertension in C5, which resolved on the same day).Figure 2.: Incidence of IRRs by cycle and grade (overall population). aThe C1D2 time point only included patients treated with bendamustine. bCycles 7 and 8 only included patients who received CVP. C = cycle; CVP = cyclophosphamide, vincristine, and prednisone; D = day; IRR = infusion-related reaction; SDI = short duration infusion.The most common IRR symptoms at any infusion rate in the overall population were nausea (23.0%), pyrexia (11.5%), and chills (10.6%). Most patients who experienced an IRR during C1 and C2 recovered/resolved their IRR. One patient discontinued the study due to an IRR during C1, and no patients discontinued due to an IRR in C2 or later (overall population). Of 113 patients in the overall population, 104 had an available response assessment at EOI. The ORR was 86.7% (98/113), including 67.3% of patients with a complete response ([CR], 76/113) and 19.5% (22/113) with a partial response. Six patients (5.3%) had progressive disease. Data were missing for the remaining 9 of 113 patients (8.0%), who were counted as nonresponders. In a subgroup of patients with fluorodeoxyglucose positron emission tomography scans evaluated by Lugano 2014 criteria9 (n = 57), the ORR at EOI was 96.5% (55/57; CR, 80.7% [46/57]; Suppl. Table S4). Mean MDASI scores were low at baseline and remained stable from baseline to EOI (Suppl. Figure S2), with a mean change in symptom severity score of −0.1 (SD, 1.4) and mean change in interference score of −0.4 (SD, 2.4). Mean MDASI scores did not differ between risk subgroups (data not shown). For the administration of obinutuzumab as an SDI compared with the standard-rate infusion, staff time savings of ≥1 hour were reported for 58 of 64 nurse evaluators (90.6%) and 44 of 51 (86.3%) physician evaluators, with a ≥4-hour time saving reported for 8 of 51 (15.7%) physicians. Compared with the standard-rate infusion, obinutuzumab SDI was considered much more convenient to administer by 42 of 64 nurse evaluators (65.6%) and 42 of 51 physician evaluators (82.4%) and was preferred by 59 of 62 nurses (95.2%) and 50 of 51 physicians (98.0%); reasons for this preference included patient and clinic/staff time savings. In summary, this study found that obinutuzumab administered as an SDI in C2 and beyond was well tolerated with no new safety signals, in patients with previously untreated, advanced FL. These results were consistent with previous studies showing the tolerability of obinutuzumab SDI in patients with diffuse large B-cell lymphoma13 and support the feasibility of obinutuzumab SDI delivery, as has been previously reported for rituximab.8,14 The higher frequency of IRRs observed with obinutuzumab- versus rituximab-chemotherapy in the GALLIUM trial5–7 did not appear to be a limitation for obinutuzumab SDI in this study. The EOI ORR from this study (86.7%) was in line with that reported in the GALLIUM trial (88.5%) using a standard 3- to 4-hour obinutuzumab infusion (~195 min).5 These results highlight that responses were essentially the same with SDI administration of obinutuzumab compared to the standard-rate infusion, regardless of infusion time. Additionally, obinutuzumab SDI demonstrated a minimal impact on patient quality of life, with relatively stable MDASI scores throughout the induction period, as well as the potential for time and cost savings. Time savings of ≥1 hour compared with the standard-rate infusion were reported by >85% of nurses and physicians, with a ≥4-hour time saving reported by 16% of physicians. The reporting of time savings of ≥4 hours, when the standard infusion rate for obinutuzumab is 3–4 hours, suggested that evaluations were based on the entire time patients were in the clinic, rather than just the infusion time. SDI administration was preferred by the majority (>95%) of healthcare providers, mainly due to the time savings for both healthcare staff and patients. Study limitations include the single-arm study design, lack of pharmacokinetic data, and relatively small number of patients, although the number of patients enrolled was in accordance with the planned sample size. In conclusion, our results suggest that obinutuzumab SDI is likely to improve the convenience for patients with FL and efficiency for infusion facilities, without compromising safety or efficacy. ACKNOWLEDGMENTS The authors thank Juana Hernandez for her contribution to the protocol writing, Maud Deraet for her contributions to the study, and Gwendoline Kok for her statistical support. Third party medical writing assistance, under the direction of Miguel Canales, was provided by Zoe Toland, BSc, and Claire Lavin, PhD, on behalf of Ashfield MedComms, an Inizio company, and was funded by F. Hoffmann-La Roche Ltd. AUTHOR CONTRIBUTIONS Study design: MAC, TAB, JPS, DK, SP, and JP. Study conduct: MAC, JPS, EV, JP, and KH. Recruitment and follow-up of patients: MAC, JAPB, TI, KI, AS, JPS, EV, KH, and LMF. Data collection: MAC, KI, JPS, EV, and KH. Data analysis: MAC, JAPB, JPS, DK, SP, JP, and KH. Data interpretation: MAC, TAB, JPS, DK, SP, EV, PT, JP, and KH. DATA AVAILABILITY Data availability information is included in the supplemental digital content. DISCLOSURES MAC reports a consultancy role with Beigene, EUSA Pharma, Celgene-BMS, Kite-Gilead, Janssen, Incyte, Karyopharm, Kyowa, Novartis, F. Hoffmann-La Roche Ltd., Sanofi, and Takeda, and honoraria from EUSA Pharma, Celgene-BMS, Kite-Gilead, Janssen, Kyowa, F. Hoffmann-La Roche Ltd., Sandoz, and Takeda. TAB reports a leadership role and is a stockholder of Nucleix and Empyrean Medical Systems, honoraria from Genentech, Inc., F. Hoffmann-La Roche Ltd., Abivax, and Precisa, a consulting or advisory role with Genentech, Inc. and F. Hoffmann-La Roche Ltd., patents, royalties, and other intellectual property with MD Anderson Cancer Center, and travel, accommodations, and expenses from Genentech, Inc. JAPB, LMF, and TI, report no conflicts. KI reports honoraria from Chugai Pharmaceutical, AbbVie, AstraZeneca, Daiichi Sankyo, Genmab, Kyowa Kirin, Novartis, Ono Pharmaceutical, Symbio, and Takeda and research funding from Chugai Pharmaceutical and Eisai. AS reports a consultancy role with Janssen, EUSA Pharma, BMS, Celgene, and Beigene, research funding from AbbVie, and a speaker’s bureau role for Janssen, BMS, and Celgene. JPS owns stock options with Centessa Pharmaceuticals, consultancy with AbbVie, AstraZeneca, Beigene, Bristol Myers Squibb, Lilly, Pharmacyclics, TG Therapeutics and Genentech, Inc., and membership on board of directors or advisory committees for Centessa Pharmaceuticals. DK reports employment with F. Hoffmann-La Roche Ltd and Celegene, and is a stockholder of F. Hoffmann-La Roche Ltd. JP reports employment with F. Hoffmann-La Roche Ltd and is a stockholder of F. Hoffmann-La Roche Ltd. SP reports employment with F. Hoffmann-La Roche Ltd. EV reports employment with IQVIA. PT reports employment with Genentech, Inc. and is a stockholder of F. Hoffmann-La Roche Ltd. KH reports employment with University of Cologne, a consultancy role with F. Hoffmann-La Roche Ltd., research funding from F. Hoffmann-La Roche Ltd., Celgene, BMS, and Janssen, honoraria from F. Hoffmann-La Roche Ltd., Servier, Gilead, Celgene, BMS, and EUSA Pharma, a speaker’s bureau role for F. Hoffmann-La Roche Ltd., Servier, Celgene, BMS, and EUSA Pharma, membership on an entity’s Board of Directors or advisory committees for F. Hoffmann-La Roche Ltd., Hexal, Novartis, Gilead, and Incyte. SOURCES OF FUNDING The GAZELLE study was sponsored by F. Hoffmann-La Roche Ltd. 

Obinutuzumab Can Be Administered as a 90-minute Short Duration Infusion in Patients With Previously Untreated Follicular Lymphoma: GAZELLE End of Induction Analysis

Abstract Follicular lymphoma (FL) is a mature B-cell neoplasm with a mostly indolent course. Genetic hallmark characteristics are Bcl-2 overexpression based on a t(14;18) translocation and additional secondary genetic and epigenetic aberrations. Standard treatment for early-stage patients has curative intent and usually consists of radiotherapy with or without rituximab. In the advanced stage, the main therapeutic focus is on prolonged remissions. Therefore, treatment in asymptomatic patients is usually deferred. Symptomatic patients are subject to immunochemotherapy induction followed by antibody maintenance. Importantly, about one in five patients subsequently experiences a more rapid clinical course, achieving only short remissions with multiple relapses (POD24). In those patients, there is still an urgent need for improved therapeutic options. Accordingly, a plethora of targeted and immunotherapeutic options, including immunomodulatory drugs, small molecule inhibitors, monoclonal antibodies as well as bispecific T-cell engager antibodies and CAR-T cell products have been recently evaluated in such relapsed high-risk patients.

Follicular lymphoma: an update on biology and optimal therapy

Abstract Follicular lymphoma is the most common indolent lymphoma accounting for approximately 20%–25% of all new non‐Hodgkin lymphoma diagnoses in western countries. Whilst outcomes are mostly favorable, the spectrum of clinical phenotypes includes high‐risk groups with significantly inferior outcomes. This review discusses recent updates in risk stratification and treatment approaches from upfront treatment for limited and advanced stage follicular lymphoma to the growing options for relapsed, refractory disease with perspectives on how to approach this from a personalized lens. Notable gaps remain on how one can precisely and prospectively select optimal treatment for patients based on varying risks, with an anticipation that an increased understanding of the biology of these different phenotypes and increasing refinement of imaging‐ and biomarker‐based tools will, in time, allow these gaps to be closed. 

Personalised therapy in follicular lymphoma – is the dial turning?

Background: The treatment of follicular lymphoma (FL) has previously centered on chemoimmunotherapy, which can be disadvantageous due to patient intolerance, cumulative toxicities, and disease refractoriness. Targeted therapies can produce deep responses and improve progression-free and overall survival with more tolerable adverse event profiles. Methods: We summarize the current literature and key clinical trials regarding targeted therapies in follicular lymphoma both in the front-line and in the relapsed-refractory setting. Results: Targeted therapies studied in FL include immune modulators, anti-CD20 antibodies, Bruton’s tyrosine kinase (BTK) inhibitors, enhancers of zeste homolog 2 (EZH2) inhibitors, phosphoinositide 3-kinase (PI3K) inhibitors, and B-cell lymphoma 2 (BCL-2) inhibitors. Chimeric antigen receptor (CAR-T) therapy and bispecific T-cell engager (BiTE) therapies also show promise in monotherapy and in combination with targeted therapies. These therapies exhibit high overall response rates and substantial progression-free survival and overall survival, even in high-risk patients or patients previously refractory to chemotherapy or rituximab. Adverse events vary substantially but are generally manageable and compare favorably to the cumulative toxicities of chemotherapy. Conclusion: Targeted therapies represent a paradigm shift in the treatment of FL. Further studies are needed to directly compare these targeted therapies and their combinations, as well as to investigate biomarkers predictive of response.

Targeted Therapy in Follicular Lymphoma: Towards a Chemotherapy-Free Approach

include five-year results from the phase III CLL14 study of fixed-duration Venclexta ® /Venclyxto ® (venetoclax) plus Gazyva ® /Gazyvaro ® (obinutuzumab) in previously untreated chronic lymphocytic leukaemia (CLL); the final analysis of the phase III GALLIUM study of Gazyva/Gazyvaro plus chemotherapy in people with previously untreated advanced-stage follicular lymphoma (FL); and subanalyses from the phase III POLARIX study of Polivy ® (polatuzumab vedotin) in combination with MabThera After a median of 65.4 months following treatment with Venclexta/Venclyxto plus Gazyva/Gazyvaro, results confirm the combination continues to be an effective fixed-duration and chemotherapy-free option for patients with previously untreated CLL and coexisting conditions. The estimated investigator-assessed progression-free survival (PFS) rate at this follow-up was 62.6% with Venclexta/Venclyxto plus Gazyva/Gazyvaro and 27.0% with Gazyva/Gazyvaro plus chlorambucil, and the estimated overall survival (OS) rate was 81.9% versus 77.0% (HR 0.72; 95% CI: 0.48-1.09; p=0.12). In addition, the analysis found that 72.1% of patients in the Venclexta/Venclyxto plus Gazyva/Gazyvaro arm did not require another treatment for CLL in the five years following initial treatment (HR 0.42; 95% CI: 0.31-0.57; p<0.0001). No new safety signals were observed.[1] The CLL14 study is being conducted in cooperation with the German CLL Study Group, headed by Michael Hallek, M.D., University of Cologne. phase After eight of follow-up in with previously untreated FL, a meaningful in PFS with Gazyva/Gazyvaro plus its a standard first-line Seven-year investigator-assessed PFS significantly improved with Gazyva/Gazyvaro plus chemotherapy (63.4%) compared with on the positive POLARIX results from the overall study population, the European Commission (EC) approved Polivy plus R-CHP in May 2022 for the treatment of adult patients DLBCL. Pivotal phase The pivotal phase II NP30179 expansion study included patients with heavily pre-treated and highly refractory DLBCL and showed fixed-duration glofitamab, an investigational CD20xCD3 T-cell engaging bispecific antibody, induced high and durable complete response (CR) rates. After a median follow-up of 12.6 months, 39.4% of patients (n=61/155) achieved a CR (primary efficacy endpoint) and half of them (51.6%; n=80/155) achieved an overall response (the percentage of patients with a partial or CR; secondary efficacy endpoint), as assessed by an independent review committee. Cytokine release syndrome (CRS) was the most common adverse event, occurring in 63.0% of patients.[4] These data were recently presented at the American Society of Clinical Oncology 2022 Annual Meeting and have been submitted for approval to the European Medicines Agency (EMA). Submissions to additional health authorities worldwide, including the U.S. Food and Drug Administration (FDA), are planned this year. and patients aged <65 and ≥65 years who had R/R prior a higher objective response rate (ORR) than those <65 years old (87.0% 77.0%, respectively). Lower rates CRS and

Roche announces positive data from broad blood cancer portfolio at European Hematology Association Annual Meeting

Background: Immunochemotherapy with rituximab plus chemotherapy (R-chemo) has significantly improved outcomes for patients (pts) with previously untreated follicular lymphoma (FL). However, most pts still experience disease relapse, progression, or death. Obinutuzumab (G) is a type II anti-CD20 monoclonal antibody with enhanced direct cell killing, antibody-dependent cellular cytotoxicity and antibody-dependent phagocytosis versus R. The safety and efficacy of G-chemo versus R-chemo was assessed in pts with previously untreated, advanced stage FL in the randomized, Phase III GALLIUM (NCT01332968) study. In the primary analysis, G-chemo demonstrated a significant improvement in progression-free survival (PFS) versus R-chemo, with a manageable safety profile (Marcus, et al. 2017); this efficacy benefit was maintained after 5 years of observation (Townsend, et al. 2020). Aims: To report the final analysis of the GALLIUM study after a median observation time of 8 years. Methods: Pts aged ≥18 years with previously untreated histologic Grade 1–3a FL requiring treatment were enrolled. Pts were randomized 1:1 to receive G 1000mg intravenously (IV; Days [D]1, 8 and 15 of Cycle 1 and D1 of subsequent cycles) or R 375mg/m2 IV (D1 of each cycle) plus chemo for 6 or 8 cycles depending on the chemo backbone selected at each institution (cyclophosphamide, doxorubicin, vincristine, and prednisolone [CHOP]; cyclophosphamide, vincristine, and prednisolone [CVP]; or bendamustine). Pts attaining a complete or partial response received maintenance with the same antibody every 2 months for 2 years or until disease progression (PD). The primary endpoint was investigator-assessed PFS; secondary endpoints included time-to-next anti-lymphoma treatment (TTNLT), overall survival (OS) and incidence of adverse events (AEs). All pts provided written informed consent. Results: 1202 pts with FL were enrolled (G-chemo, n=601; R-chemo, n=601). As of July 30, 2021, median observation time was 8 years. Seven-year PFS was improved with G-chemo (63.4%) versus R-chemo (55.7%; hazard ratio [HR], 0.77; 95% confidence interval [CI]: 0.64–0.93; p=0.006; Figure). TTNLT was also improved with G-chemo versus R-chemo (HR, 0.71; 95% CI: 0.58–0.87; p=0.001); the proportion of pts who had not started their next treatment at 7 years was 74.1% and 65.4%, respectively. Disease transformation was observed in 4.2% of pts with G-chemo and 5.0% of pts with R-chemo. Seven-year OS was similar in both arms, 88.5% with G-chemo versus 87.2% with R-chemo (HR, 0.86; 95% CI: 0.63–1.18; p=0.36). Seventy-five pts in the G-chemo arm and 86 pts in the R-chemo arm had died, most commonly due to PD (4.2% and 6.0%, respectively). The incidence of serious AEs (SAEs) was 48.9% with G-chemo (28.2% and 24.4% during induction and maintenance, respectively) and 43.4% with R-chemo (24.6% and 21.7%, respectively). Rates of fatal AEs were similar with G-chemo (4.4%) and R-chemo (4.5%); pneumonia was the most common fatal AE (0.8% [n=5] and 0.2% [n=1], respectively) and SAE (5.9% [n=35] and 6.2% [n=37], respectively). Second malignancies occurred in 13.1% of pts in the G-chemo arm and 9.9% of pts in the R-chemo arm. After adjusting for observation time, rates were similar between arms. These safety findings are consistent with previous analyses. Image:Summary/Conclusion: After a median observation time of 8 years, a meaningful improvement in PFS was maintained with G-chemo versus R-chemo in pts with previously untreated FL, confirming the role of G-chemo as a standard of care for the first-line treatment of pts with FL. 

S206: obinutuzumab plus chemotherapy demonstrates long-term benefit over rituximab plus chemotherapy in patients with previously untreated follicular lymphoma: final analysis of the gallium study

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S206: obinutuzumab plus chemotherapy demonstrates long-term benefit over rituximab plus chemotherapy in patients with previously untreated follicular lymphoma: final analysis of the gallium study