The redox biology of redox-inert zinc ions.

Zinc is an essential requirement for normal cellular processes and is involved in the function of more than 300 enzymes. Currently, it is estimated that approximately 10 % of the proteins encoded by the human genome contain zinc. Zinc is necessary for neuromodulation, synaptic transmission, intracellular signal transduction, and myriad other processes. The clinical implications of impaired zinc signaling are, therefore, far reaching, with profound central and peripheral disorders arising as a result of either an acute or a long-term dyshomeostasis in normal zinc levels. Targeting zinc as a therapy is now emerging as a tantalizing, although especially difficult, approach to a variety of diseases, including central nervous system disorders. This chapter reviews the clinical implications of impaired zinc signaling in the brain.

The Clinical Implications of Impaired Zinc Signaling in the Brain

Allwissend bin ich nicht; doch viel ist mir bewusst.

/pdf/strategies-to-potentiate-the-cellular-poly-adp-ribosyl-ation-3tynsyta43.pdf

Strategies to Potentiate the Cellular Poly(ADP-ribosyl)ation Response to DNA Damage

One of the hallmarks of ageing is the increased susceptibility to develop age-related diseases such as infections and cancers. This is believed to be favoured by a decline in the function of the innate and adaptive immune systems, a process known as immunosenescence. The current greying of the world population leads to the potential dilemma of increasing life expectancy without the concomitant increase in the quality of life with more individuals acquiring age-related disorders. Ultimately this may have profound socio-economic implications for those in positions of government and strategic policy makers. With this in mind, this chapter reviews the current understanding of some of the causes of immunosenescence and looks to address the question, “Can immunosenescence be corrected or reversed?”

Immunosenescence and the 3Rs: Restoration, Replacement and Reprogramming

Zinc and ageing.

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Zinc and ageing.