E. Michael Gertz
National Institutes of Health
56 Papers
178 Citations
E. Michael Gertz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 23, co-authored 48 publications. Previous affiliations of E. Michael Gertz include University of Wisconsin-Madison & Argonne National Laboratory.
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Papers
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
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Protein database searches using compositionally adjusted substitution matrices
Stephen F. Altschul,John C. Wootton,E. Michael Gertz,Richa Agarwala,Aleksandr Morgulis,Alejandro A. Schäffer,Yi-Kuo Yu +6 more
TL;DR: This work has recently developed a general procedure for transforming a standard matrix into one appropriate for the comparison of two sequences with arbitrary, and possibly differing compositions.
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Composition-based statistics and translated nucleotide searches: Improving the TBLASTN module of BLAST
TL;DR: It is shown that composition-based statistics greatly improve the statistical accuracy of TBLASTN, at a small cost to the retrieval accuracy, and is useful in other studies of translated search algorithms.
A Fast and Symmetric DUST Implementation to Mask Low-Complexity DNA Sequences
TL;DR: A new implementation of the DUST module that uses the same function to assign a complexity score to a sequence, but uses a different rule by which high-scoring sequences are masked, at least four times faster than the old on the human genome.
Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity
G Lopez-Herrera,Giacomo Tampella,Qiang Pan-Hammarström,Peer Herholz,Claudia M. Trujillo-Vargas,Claudia M. Trujillo-Vargas,Kanchan Phadwal,Anna Katharina Simon,Anna Katharina Simon,Michel Moutschen,Amos Etzioni,Adi Mory,Izhak Srugo,Doron Melamed,Kjell Hultenby,Chonghai Liu,Chonghai Liu,Manuela Baronio,Massimiliano Vitali,Pierre Philippet,Vinciane Dideberg,Asghar Aghamohammadi,Nima Rezaei,Victoria Enright,Likun Du,Ulrich Salzer,Hermann Eibel,Dietmar Pfeifer,Hendrik Veelken,Hans J. Stauss,Vassilios Lougaris,Alessandro Plebani,E. Michael Gertz,Alejandro A. Schäffer,Lennart Hammarström,Bodo Grimbacher +35 more
TL;DR: It is concluded that mutations in LRBA cause an immune deficiency characterized by defects in B cell activation and autophagy and by susceptibility to apoptosis, all of which are associated with a clinical phenotype of hypogammaglobulinemia and autoimmunity.
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