E. Jay Rehm
Yale University
3 Papers
167 Citations
E. Jay Rehm is an academic researcher from Yale University. The author has contributed to research in topics: Comparative genomics & Enhancer. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of E. Jay Rehm include University of Chicago.
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Papers
Comparative analysis of regulatory information and circuits across distant species
Alan P. Boyle,Carlos L. Araya,Cathleen M. Brdlik,Philip Cayting,Chao Cheng,Yong Cheng,Kathryn E. Gardner,LaDeana W. Hillier,J. Janette,Lixia Jiang,Dionna M. Kasper,Trupti Kawli,Pouya Kheradpour,Anshul Kundaje,Anshul Kundaje,Jingyi Jessica Li,Jingyi Jessica Li,Lijia Ma,Wei Niu,E. Jay Rehm,Joel Rozowsky,Matthew Slattery,Rebecca Spokony,Robert Terrell,D. Vafeados,Daifeng Wang,Peter Weisdepp,Yi-Chieh Wu,Dan Xie,Koon-Kiu Yan,Elise A. Feingold,Peter J. Good,Michael J. Pazin,Haiyan Huang,Peter J. Bickel,Steven E. Brenner,Valerie Reinke,Robert H. Waterston,Mark Gerstein,Kevin P. White,Manolis Kellis,Michael Snyder +41 more
TL;DR: The results suggest that gene-regulatory properties previously observed for individual factors are general principles of metazoan regulation that are remarkably well-preserved despite extensive functional divergence of individual network connections.
Comparative analysis of regulatory information and circuits across distant species
Alan P. Boyle,Carlos L. Araya,Cathleen M. Brdlik,Philip Cayting,Chao Cheng,Yong Cheng,Kathryn E. Gardner,LaDeana W. Hillier,J. Janette,Lixia Jiang,Dionna M. Kasper,Trupti Kawli,Pouya Kheradpour,Anshul Kundaje,Anshul Kundaje,Jingyi Jessica Li,Jingyi Jessica Li,Lijia Ma,Wei Niu,E. Jay Rehm,Joel Rozowsky,Matthew Slattery,Rebecca Spokony,Robert Terrell,D. Vafeados,Daifeng Wang,Peter Weisdepp,Yi-Chieh Wu,Dan Xie,Koon-Kiu Yan,Elise A. Feingold,Peter J. Good,Michael J. Pazin,Haiyan Huang,Peter J. Bickel,Steven E. Brenner,Valerie Reinke,Robert H. Waterston,Mark Gerstein,Kevin P. White,Manolis Kellis,Michael Snyder +41 more
- 01 Aug 2014
TL;DR: In this article, the genome-wide binding locations of 165 human, 93 worm and 52 fly transcription regulatory factors were mapped for a total of 1,019 data sets from diverse cell types, developmental stages, or conditions in the three species, of which 498 (48.9%) are presented here for the first time.
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Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster
Matthew Slattery,Lijia Ma,Rebecca Spokony,Robert K. Arthur,Pouya Kheradpour,Anshul Kundaje,Nicolas Nègre,Nicolas Nègre,Alex Crofts,Ryan Ptashkin,Jennifer Zieba,Alexander Ostapenko,Sarah Suchy,Alec Victorsen,Nader Jameel,A. Jason Grundstad,Wenxuan Gao,Jennifer R. Moran,E. Jay Rehm,Robert L. Grossman,Manolis Kellis,Manolis Kellis,Kevin P. White +22 more
TL;DR: An updated map of the Drosophila melanogaster regulatory genome based on the location of 84 TRFs at various stages of development reveals a variety of genomic targeting patterns, including factors with strong preferences toward proximal promoter binding, factors that target intergenic and intronic DNA, and factors with distinct chromatin state preferences.