E. Jacobs
University of Nottingham
11 Papers
291 Citations
E. Jacobs is an academic researcher from University of Nottingham. The author has contributed to research in topics: Monoclonal antibody & Cytotoxicity. The author has an hindex of 9, co-authored 11 publications.
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Papers
Preparation and properties of a drug-carrier-antibody conjugate showing selective antibody-directed cytotoxicity in vitro.
TL;DR: Results indicate that a drug‐carrier antibody conjugate can be synthesized which has all the in vitro properties theoretically necessary for a successful antibody‐targeted cytotoxic agent.
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Antitumor properties of vindesine-monoclonal antibody conjugates.
G.F. Rowland,C.A. Axton,Robert W. Baldwin,Joseph P. Brown,J.R.F. Corvalan,M. J. Embleton,V. A. Gore,Ingegerd Hellström,Karl Erik Hellström,E. Jacobs,C. H. Marsden,Malcolm V. Pimm,R.G. Simmonds,W. Smith +13 more
TL;DR: The anticancer alkaloid vindesine (VDS) was conjugated to four mouse monoclonal antibodies recognizing human tumor-associated antigens and the most marked antitumor effects observed were those obtained with VDS conjugates of the anti-CEA antibodies against a colorectal tumor xenograft.
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An idiotypic replica of carcinoembryonic antigen inducing cellular and humoral responses directed against human colorectal tumours.
Lindy G. Durrant,G. W. L. Denton,E. Jacobs,M. Mee,Robert Moss,E. B. Austin,Robert W. Baldwin,Jack D. Hardcastle,R. A. Robins +8 more
TL;DR: The results suggest that 708 anti‐Id MAb can act as an idiotypic replica of CEA and stimulate cellular and humoral anti‐CEA immune responses.
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A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate.
Malcolm V. Pimm,R. A. Robins,M. J. Embleton,E. Jacobs,A. J. Markham,A. Charleston,Robert W. Baldwin +6 more
TL;DR: Purified hybrid antibody specifically enhanced the in vitro cytotoxicity of MTX-HSA for gp72 positive tumour cells and dual binding between tumour cell surface antigen and MTX was demonstrated.
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•Journal Article
Studies on the mechanism of action of an antibody-targetted drug-carrier conjugate.
TL;DR: Conjugate cytotoxicity was reduced by ammonium chloride suggesting that endocytosis and an acidic internal compartment were involved in the mechanism of action, and aspects of the mechanisms of action investigated by the effects of specific inhibitors of biochemical processes on conjugate cyttoxicity.
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