E. Imperiale
University of Turin
18 Papers
155 Citations
E. Imperiale is an academic researcher from University of Turin. The author has contributed to research in topics: Growth hormone secretion & Pyridostigmine. The author has an hindex of 11, co-authored 18 publications. Previous affiliations of E. Imperiale include University of Milan.
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Papers
Effect of cholinergic enhancement by pyridostigmine on growth hormone secretion in obese adults and children
Ezio Ghigo,Ezio Ghigo,E. Mazza,E. Mazza,Andrea Corrias,Andrea Corrias,E. Imperiale,E. Imperiale,S. Goffi,S. Goffi,Emanuela Arvat,Emanuela Arvat,Jaele Bellone,Jaele Bellone,C. De Sanctis,C. De Sanctis,E. E. Muller,E. E. Muller,Franco Camanni,Franco Camanni +19 more
TL;DR: PD is able to potentiate the blunted GH responses to GHRH in obese adults and children, inducing a GH increase similar to that observed after G HRH alone in normal subjects, suggesting that an alteration of somatostatinergic tone could be involved in the reduced GH secretion in obesity.
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Glucagon stimulates GH secretion after intramuscular but not intravenous administration. Evidence against the assumption that glucagon per se has a GH-releasing activity.
Ezio Ghigo,E. Bartolotta,E. Imperiale,Jaele Bellone,G. Cardinale,Gianluca Aimaretti,M. R. Valetta,Valentino Cherubini,Mauro Maccario,Daniela Cocchi,Franco Camanni +10 more
TL;DR: It is demonstrated that glucagon perse has not GH-releasing activity as indicated by its uneffectiveness to release GH in vitro and after intravenous administration and the mechanisms underlying the GH increase which follows intramuscular administration are not clear.
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A new test for the diagnosis of growth hormone deficiency due to primary pituitary impairment: combined administration of pyridostigmine and growth hormone-releasing hormone
Ezio Ghigo,E. Imperiale,G. M. Boffano,E. Mazza,Jaele Bellone,Emanuela Arvat,Massimo Procopio,S. Goffi,Antonella Barreca,P. Chiabotto,Roberto Lala,C. de Sanctis,M. F. Boghen,E. E. Müller,Franco Camanni +14 more
TL;DR: In slowly growing children PD + GHRH test is the most reliable provocative test for the diagnosis of primary pituitary GH deficiency being capable to discriminate between an unequivocally normal and impaired somatotropic function.
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Growth hormone responses to pyridostigmine in normal adults and in normal and short children.
TL;DR: The data show that cholinergic enhancement by PD induces a higher GH increase in both normal and short children than that observed in adults, which indicates that PD test may be considered a more potent GH provocative stimulus than insulin hypoglycaemia.
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Cholinergic Enhancement by Pyridostigmine Potentiates Spontaneous Diurnal but not Nocturnal Growth Hormone Secretion in Short Children
TL;DR: The ability of PD to increase GH secretion during the morning but not GH hypersecretion occurring at night implies that the cholinergic tone in the central nervous system areas controlling GH secretion is already maximally stimulated at night.
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