E. Huybrechts
Katholieke Universiteit Leuven
6 Papers
38 Citations
E. Huybrechts is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Thromboplastin & Thromboxane-A synthase. The author has an hindex of 5, co-authored 6 publications.
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Papers
Optimization of the dilute prothrombin time for the detection of the lupus anticoagulant by use of a recombinant tissue thromboplastin.
TL;DR: Analysis of 316 consecutive plasma samples from nonanticoagulated patients, showed a 100% sensitivity and a 96% specificity of the dPT performed with Innovin, as compared to 81% and 93% respectively for the d PT using Simplastin.
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A new lupus anticoagulant neutralization test based on platelet-derived vesicles.
TL;DR: An easily standardizable and reproducible procedure which clearly separates lupus anticoagulants (LA) from coagulation factor inhibitors and segregation of LA patients from all remaining patients except heparinized ones could be made with a high degree of accuracy.
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Detection of lupus-like anticoagulants by an enzyme-linked immunosorbent assay using a partial thromboplastin as antigen; a comparative study.
TL;DR: It is indicated that ELISA techniques cannot entirely replace coagulation tests for the detection of a lupus anticoagulant, even when a partial thromboplastin is used as antigen.
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Generation of arachidonic acid metabolites from stimulated whole blood in patients with chronic myeloproliferative disorders.
P. Parise,E. Huybrechts,S. Grasselli,Francesca Falcinelli,G.G. Nenci,Paolo Gresele,Jozef Vermylen +6 more
TL;DR: It is confirmed that the arachidonate metabolism is frequently deranged in patients with MPD and the opposite changes in thromboxane formation in ET and PV could be one of the factors responsible for the different incidences of thrombotic and hemorrhagic complications in these diseases.
7
Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.
TL;DR: Prostaglandin endoperoxides can partly substitute for the activity of TXA2 in vivo in man and that an increased formation of endogenous antiaggregatory and vasodilatory prostaglandins, as obtained with selective thromboxane synthase inhibitors, may contribute to the impairment of hemostasis.