E. Boncompte
9 Papers
99 Citations
E. Boncompte is an academic researcher. The author has contributed to research in topics: Azole & Flutrimazole. The author has an hindex of 7, co-authored 9 publications.
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Papers
New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones
Javier Bartroli,Enric Turmo,Mònica Algueró,E. Boncompte,Maria L. Vericat,Lourdes Conte,Joaquim Ramis,Manuel Merlos,Julian Garcia-Rafanell,Javier Forn +9 more
TL;DR: In vitro 20 was superior to fluconazoles, itraconazole, SCH-42427, and TAK-187 and roughly similar to voriconazole and ER-30346, and in vivo 20 showed excellent protection levels in an immunocompromised rat model of disseminated aspergillosis.
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New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol
Javier Bartroli,Enric Turmo,Mònica Algueró,E. Boncompte,Maria L. Vericat,Lourdes Conte,Joaquim Ramis,Manuel Merlos,Julian Garcia-Rafanell,Javier Forn +9 more
TL;DR: The nature and substitution of the amide portion was systematically modified in search of improved antifungal activity, especially against filamentous fungi and it was proven that only an orthogonal orientation of the phenyl ring yields bioactive products.
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Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring.
J. Bartroli,Enric Turmo,Mònica Algueró,E. Boncompte,Maria L. Vericat,Julian Garcia-Rafanell,Javier Forn +6 more
TL;DR: A series of azole derivatives carrying an N-acylmorpholine ring are described, chemically designed to simulate the lanosterol D ring, taking advantage of the conformational preferences of 2-alkyl-1-ACYlmorpholines.
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Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release® cream (1, 2 and 4%) with placebo site-release® vaginal cream
Amalia del Palacio,Francisca Sanz,Gracia Sánchez-Alor,Margarita Garau,María‐Teresa Calvo,E. Boncompte,Mònica Algueró,Caridad Pontes,A. Gómez de la Cámara +8 more
TL;DR: A double‐blind randomized comparative phase II study of flutrimazole site‐release vaginal cream with placebo site‐released vaginal cream was undertaken in patients with acute vulvovaginal candidosis, finding no significant differences in clinical and mycological activity between the three active groups.
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