Background
Dialysis disequilibrium syndrome (DDS) is the clinical phenomenon of acute neurologic symptoms attributed to cerebral edema that occurs during or following intermittent hemodialysis (HD). We describe a case of DDS-induced cerebral edema that resulted in irreversible brain injury and death following acute HD and review the relevant literature of the association of DDS and HD.

/pdf/dialysis-disequilibrium-syndrome-brain-death-following-1tk9kdb5y8.pdf

Dialysis Disequilibrium Syndrome: Brain death following hemodialysis for metabolic acidosis and acute renal failure – A case report

Glomerular fibrinolytic activity in anti-GBM glomerulonephritis in rabbits

We employed the so-called event-correlated potential (ECP) P300, a neurophysiological test which explores the circuits of attention and memory in the brain and is altered in subjects with a dismetabolic or degenerative encephalopathy, in order to evaluate the cognitive faculty in two groups of uremic patients [18 on continuous ambulatory peritoneal dialysis (CAPD), 15 on hemodialysis (HD)] comparable with respect to age and time on dialysis. The values of latency (msec) of P300 resulted in CAPD patients 356 +/- 26 in CZ (central zero electrodes) and 357.5 +/- 25 in PZ (parietal zero electrodes), not significantly different from the values in normal controls (341 +/- 14.5 in CZ and 340 +/- 15.6 in PZ) and in HD patients postdialysis (354 +/- 24.4 in CZ and 354 +/- 25.6 in PZ). On the contrary, the predialytic values of HD patients (384 +/- 25.6 CZ and 385 +/- 25.5 in PZ) were significantly different from the postdialytic values and from the values of CAPD patients and controls (p < 0.01). These results support the conclusion that HD is able to restore a normal cognitive faculty only transiently in the postdialytic phase, while CAPD maintains this important function steadily close to the normal range, thus being clearly better than HD.

Better Preservation of Cognitive Faculty in Continuous Ambulatory Peritoneal Dialysis

https://www.kidney-international.org/article/S0085-2538(15)34899-7/pdf

Secretion of plasminogen activator and its inhibitor by glomerular epithelial cells

https://www.neurologic.theclinics.com/article/S0733-8619(03)00052-5/pdf

Neurologic manifestations of renal disease.

Effect of calcium and hydrogen ion on the fibrinolytic activity of isolated renal glomeruli from rat.

In five patients with chronic renal failure, rapid correction by dialysis of hypertension and/or high blood urea levels provoked acute neurological disorders, followed by slowly reversible neuropsychiatric disturbances. Focal EEG alterations were noted in three patients with normal carotid angiograms. Our cases differed from those usually described as suffering from the dialysis disequilibrium syndrome because of their duration, the severity of mental disturbances, and the asymmetrical pattern of EEG abnormalities. We propose that the symptoms observed could be due to cerebral ischemia. This possibility emphasizes the importance of limiting the duration and efficiency of the first dialyses in patients with severe hypertension and high nitrogen retention, especially if high performance dialyzers are used.

Unusual aspects of the dialysis disequilibrium syndrome.

<h3>Objectives</h3> Efficiency and toxicity of hypofractionated Stereotactic Body Radiation Therapy (SBRT) in pediatric situations need to be assessed. We conducted a prospective multicentric National study on SBRT in young patients (1.5-20 y.) <h3>Methods</h3> Indications of SBRT had to be approved by a multi-disciplinary tumor board. SBRT indications were either locally relapsed ependymoma after complete surgery (randomization between 24 Gy/3 fr or 25 Gy/5 fr, isodose 80%), or brain, lung or spinal metastases of any origin after incomplete or no resection in first-line, or in re-irradiation (re-RT) situations The main objective was to evaluate the 6-month local control (LC) rate (RECIST 1.1). Secondary objectives were to evaluate 1 and 2-year LC rates, acute (< 3 months) and medium-term toxicities (3-24 months) using NCI-CTC-v-4.0. <h3>Results</h3> Sixty-one patients, median age 13y., (range 3-20) were included in 10 institutions (12/2013-12/2019). Four patients did finally not receive SBRT and were excluded from the analysis. Eighteen patients (32%) were irradiated in first intention (5 brain, 5 lung, 8 spinal lesions, median dose 35 Gy/5fr, isodose 80%. Thirty-nine patients (68 %) were included for re-RT: 14 patients (7 patients/randomization arm) for post-operative SBRT for locally relapsed ependymoma, 25 patients for re-RT in other situations (brain, spine, lung…) (median dose 25 Gy/5 fr, isodose 80%). No pt required general anesthesia. Median follow-up was 24 months (22-28 months). Six-month, 1- and 2-year local control rates will be reported during the congress (undergoing analysis). Gr.2 and 3 acute RT toxicities were observed in 7 and 1 (epilepsy) patients respectively. Medium-term RT toxicity was identified in 4 patients (gr.2) and 1 patients (gr.3, brain radio-necrosis). No grade 4/5 was reported. <h3>Conclusion</h3> SBRT is feasible and safe in childhood in selected brain, lung and spine treatment or in selected cases of re-RT. More details (especially efficiency) will be available for the congress. 

Hypofractionated stereotactic body radiation therapy (SBRT) in pediatric patients: results of a national prospective multicenter study

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

E. Blanc

Author Tools

Chat about Author

Papers

Effect of calcium and hydrogen ion on the fibrinolytic activity of isolated renal glomeruli from rat.

Unusual aspects of the dialysis disequilibrium syndrome.

Hypofractionated stereotactic body radiation therapy (SBRT) in pediatric patients: results of a national prospective multicenter study