Dylan J. Dues
Van Andel Institute
20 Papers
35 Citations
Dylan J. Dues is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of Dylan J. Dues include Central Michigan University.
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Papers
Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan
Claire E. Schaar,Dylan J. Dues,Katie K. Spielbauer,Emily Machiela,Jason F. Cooper,Megan M. Senchuk,Siegfried Hekimi,Jeremy M. Van Raamsdonk +7 more
TL;DR: To genetically dissect the subcellular compartment in which elevated ROS act to increase lifespan, individual superoxide dismutase (sod) genes in clk-1 mutants are deleted, finding that only deletion of the primary mitochondrial sod gene, sod-2 results in increased lifespan in clK-1 worms.
Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.
Megan M. Senchuk,Dylan J. Dues,Claire E. Schaar,Benjamin K. Johnson,Zachary Madaj,Megan J. Bowman,Mary E. Winn,Jeremy M. Van Raamsdonk,Jeremy M. Van Raamsdonk,Jeremy M. Van Raamsdonk +9 more
TL;DR: This work reveals an overlapping genetic pathway required for longevity in three mitochondrial mutants, and demonstrates that DAF-16 is a downstream mediator of lifespan extension in multiple pathways of longevity.
Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
Ziyun Wu,Ziyun Wu,Megan M. Senchuk,Dylan J. Dues,Benjamin K. Johnson,Jason F. Cooper,Leira Lew,Emily Machiela,Claire E. Schaar,Heather DeJonge,T. Keith Blackwell,T. Keith Blackwell,Jeremy M. Van Raamsdonk +12 more
TL;DR: It is suggested that the mitoUPR causes atfs-1-dependent changes in the expression of genes involved in stress response and metabolism, which contributes to the extended longevity observed in this mutant.
Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.
Dylan J. Dues,Claire E. Schaar,Benjamin K. Johnson,Megan J. Bowman,Mary E. Winn,Megan M. Senchuk,Jeremy M. Van Raamsdonk,Jeremy M. Van Raamsdonk +7 more
TL;DR: Overall, this work shows that the increased resistance to oxidative stress in isp‐1 worms does not account for their longevity, and that resistance to antioxidant stress can be experimentally dissociated from lifespan.
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Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays
Megan M. Senchuk,Dylan J. Dues,Jeremy M. Van Raamsdonk +2 more
- 05 Jan 2017
TL;DR: Sensitivity to oxidative stress is a balance between basal levels of ROS, the ability to detoxify ROS, and the able to repair ROS-mediated damage.