Dylan C. Thomas
Boston University
4 Papers
1 Citations
Dylan C. Thomas is an academic researcher from Boston University. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Dylan C. Thomas include Boston Medical Center.
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Papers
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
Katherine B. McCauley,Finn Hawkins,Finn Hawkins,Maria Paola Serra,Maria Paola Serra,Dylan C. Thomas,Anjali Jacob,Anjali Jacob,Darrell N. Kotton,Darrell N. Kotton +9 more
TL;DR: It is shown that cyclical modulation of the canonical Wnt signaling pathway enables rapid directed differentiation of human iPSCs via an NKX2-1+ progenitor intermediate into functional proximal airway organoids.
401
Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells
Finn Hawkins,Philipp Kramer,Anjali Jacob,Ian Driver,Dylan C. Thomas,Katherine B. McCauley,Nicholas Skvir,Ana M. Crane,Anita A. Kurmann,Anthony N. Hollenberg,Sinead Nguyen,Brandon G. Wong,Ahmad S. Khalil,Ahmad S. Khalil,Sarah X.L. Huang,Sarah X.L. Huang,Susan H. Guttentag,Jason R. Rock,John M. Shannon,Brian R. Davis,Darrell N. Kotton +20 more
TL;DR: In this paper, a set of human primordial lung progenitors were derived from embryonic, endodermal, NK2 homeobox 1-expressing (NKX2-1+) precursor cells.
Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells.
Anjali Jacob,Marall Vedaie,Marall Vedaie,David A Roberts,David A Roberts,Dylan C. Thomas,Dylan C. Thomas,Carlos Villacorta-Martin,Konstantinos-Dionysios Alysandratos,Konstantinos-Dionysios Alysandratos,Finn Hawkins,Finn Hawkins,Darrell N. Kotton,Darrell N. Kotton +13 more
TL;DR: A detailed protocol for the directed differentiation of hPSCs into self-renewing AEC2-like cells that can be maintained for up to 1 year in culture as epithelial-only spheres without the need for supporting mesenchymal feeder cells is provided.
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Reversible restriction of electron flow across cytochrome b6f in dark acclimated cells limited for downstream electron sinks
Shai Saroussi,Devin A.J. Karns,Dylan C. Thomas,Petra Redekop,Tyler M. Wittkopp,Matthew C. Posewitz,Arthur R. Grossman +6 more
TL;DR: A biological ‘switch’ in the green alga Chlamydomonas reinhardtii is described that reversibly restricts photosynthetic electron transport at the cytochrome b6f complex when reductant and ATP generated by PET are in excess of the capacity of carbon metabolism to utilize these products.