Dwight M. Chambers
Georgia Institute of Technology
5 Papers
Dwight M. Chambers is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Biology & Extracellular matrix. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Dwight M. Chambers include The Wallace H. Coulter Department of Biomedical Engineering.
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Papers
Frustrated Phagocytic Spreading of J774A-1 Macrophages Ends in Myosin II-Dependent Contraction.
Daniel T. Kovari,Wenbin Wei,Patrick Chang,Jan-Simon Toro,Ruth Fogg Beach,Dwight M. Chambers,Karen Porter,Doyeon Koo,Jennifer E. Curtis +8 more
TL;DR: It is found that late-stage contraction initiates after the cell surface area increases by 225%, which is consistent with the point at which cortical tension begins to rise, and reducing tension by exposing cells to hypertonic buffer shifts the onset of contraction to occur in larger contact areas.
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Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion
Victoria L. Stefanelli,Shilpa Choudhury,Ping Hu,Yining Liu,Anja Schwenzer,Chiuan-Ren Yeh,Dwight M. Chambers,Kelly Pesson,Wei Li,Tatiana Segura,Kim S. Midwood,Matthew P. Torres,Thomas H. Barker +12 more
TL;DR: The precise manner in which the ECM protein fibronectin undergoes the posttranslational modification citrullination in response to peptidyl-arginine deiminase (PAD) is demonstrated, establishing a direct link between inflammation and tissue homeostasis and pathogenesis through the matrix.
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Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures.
Tom Bongiorno,Jeremy Gura,Priyanka Talwar,Dwight M. Chambers,Katherine M. Young,Dalia Arafat,Gonghao Wang,Emily Jackson-Holmes,Peng Qiu,Todd C. McDevitt,Todd Sulchek,Todd Sulchek,Todd Sulchek +12 more
TL;DR: The results of this study indicate that intrinsic cell mechanical properties might serve as a basis for efficient, high-throughput, and label-free isolation of pluripotent stem cells, which will facilitate a greater biological understanding of pluropotency and advance the potential of plurIPotent stem cell differentiated progeny as cell sources for tissue engineering and regenerative medicine.
LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol.
Dwight M. Chambers,Leandro Moretti,Jennifer J. Zhang,Spencer W. Cooper,Davis M. Chambers,Philip J. Santangelo,Thomas H. Barker +6 more
TL;DR: It is shown that LEMD3–SMAD2/3 interactions are inversely correlated with ECM stiffness and TGFβ-driven luciferase activity and that LemD3 expression is correlated with the mechanical response of the TGF β-driven Luciferase reporter.