Duane E. Day
Henry Ford Hospital
16 Papers
339 Citations
Duane E. Day is an academic researcher from Henry Ford Hospital. The author has contributed to research in topics: Plasminogen activator inhibitor-1 & Plasminogen activator. The author has an hindex of 12, co-authored 16 publications. Previous affiliations of Duane E. Day include University of Illinois at Chicago & Henry Ford Health System.
Chat about Author
Papers
A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1 EVIDENCE FOR REACTIVE CENTER LOOP INSERTION AND ITS ROLE IN THE INHIBITORY MECHANISM
Joseph D. Shore,Duane E. Day,Ann Marie Francis-Chmura,Ingrid M. Verhamme,Jan Kvassman,Daniel A. Lawrence,David Ginsburg +6 more
TL;DR: Results demonstrate experimentally that complexation with proteases is presumably associated with loop insertion and that in the stable protease-PAI-1 complex the reactive center loop is cleaved and inserted into β sheet A and that this process is central to the inhibition mechanism.
132
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
Daniel A. Lawrence,Steven T. Olson,Shabazz Muhammad,Duane E. Day,Jan-Olov Kvassman,David Ginsburg,Joseph D. Shore +6 more
TL;DR: The present study demonstrates that partitioning between inhibitor and substrate modes of reaction can be altered by varying either the rates of RCL insertion or deacylation using a library of serpin RCL mutants substituted in the critical P14 hinge residue and three different proteinases.
114
Accelerated Conversion of Human Plasminogen Activator Inhibitor-1 to Its Latent Form by Antibody Binding *
Ingrid M. Verhamme,Jan-Olov Kvassman,Duane E. Day,Sophie Debrock,Nele Vleugels,Paul Declerck,Joseph D. Shore +6 more
TL;DR: Observations are consistent with this idea and suggest that the equilibrium involves partial insertion of the RCL into sheet A: latent, RCL-cleaved, and tPA-complexed PAI-1, which are inactive loop-inserted forms, bound much faster than active PAi-1 to MA-33B8, whereas two loop-extracted forms of PAI
79
Acceleration of surface-dependent autocatalytic activation of blood coagulation factor XII by divalent metal ions.
TL;DR: Investigation of the effect of Zn2+ on factor XII activation demonstrated a complete dependence on the presence of dextran sulfate, lack of inhibition by soybean trypsin inhibitor, the appearance of alpha-XIIa as the primary reaction product, and reaction kinetics characteristic of an autocatalytic process.
44
Mutants of Plasminogen Activator Inhibitor-1 Designed to Inhibit Neutrophil Elastase and Cathepsin G Are More Effective in Vivo than Their Endogenous Inhibitors
Steingrimur Stefansson,Manuel Yepes,Natalia Gorlatova,Duane E. Day,Elisabeth G. Moore,Adriana Zabaleta,Grainne A. McMahon,Daniel A. Lawrence +7 more
TL;DR: PAI-1 mutants were more effective in reducing the neutrophil elastase and cathepsin G activities in an in vivo model of lung inflammation than were their physiological inhibitors.
34