The invention is related to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, ester, and/ or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Novel hiv reverse transcriptase inhibitors

Purpose: To investigate the role of a thiol-containing biologically active compound in lipid peroxidation of membranes. Materials and methods: Thiyl radicals were generated from 3-(2-mercaptoethyl)quinazoline-2,4(1H,3H)-dione (MECH) using pulse radiolysis and gamma -radiolysis in aqueous and alcoholic solutions saturated with N2O. The products were analysed by 1H NMR and by HPLC. Results: The thiyl radicals abstract bisallylic hydrogens from {cis-9,cis-12}-methyl linoleate, yielding a pentadienyl radical. In the absence of oxygen, a thiyl radical-induced cis/trans-isomerization leads to linoleic-type isomers. These chain-type isomerization reactions can occur with the long living pentadienyl radical, followed by a 'repair' reaction of the attached thiol, and with the thiyl radical adduct with a double bond of the fatty acid residue. Conclusions: The results show that the mechanism of cis/trans isomerization is an integral part of the thiyl radical attack on polyunsaturated fatty acids in homogeneous solut...

Thiyl radical-induced cis/trans-isomerization of methyl linoleate in methanol and of linoleic acid residues in liposomes.

Compounds of formula (I): wherein R 1 , R 2 , and R 3 are defined in the specification. The compounds are useful for treating or reducing the risk of reversible obstructive airways disease.

Thieno[2,3-d]pyrimidine-2,4-diones

The aim of the invention is the discovery and investigation of novel chemical entities of a non-proteinogenic structure which have a matrix-metalloproteinase(MMP)-inhibiting effect. Said aim is achieved by means of the synthesis of dimercaptoalkyl-substituted quinazolin-2,4(1H,3H)-diones. Compounds of the above substance class display an unexpectedly clear and hence pharmacologically interesting MMP-inhibiting effect.

New 1-(dimercaptoalkyl)-quinazoline-2,4(1H,3H)-diones, are stable matrix metalloproteinase inhibitors useful e.g. for treating rheumatism, tumor metastasis or sunburn

Reactions of [1]benzothieno[3,2-e][1,3]oxazolo[3,2-a]pyrimidin-11-ium bromide with oxygen-containing nucleophiles involve opening of the dihydrooxazole ring and lead to the formation of new functionally substituted thieno[2,3]-d]pyrimidine derivatives.

Thienooxazolopyrimidinium salts. Reaction of 1-bromomethyl-5-oxo-4-phenyl-1,2,4,5,6,7,8,9-octahydro[1]benzothieno-[3,2-e][1,3]oxazolo[3,2-a]pyrimidin-11-ium bromide with oxygen-centered nucleophiles

of EP0454060The invention relates to 3-(mercaptoalkyl) quinazoline-2,4(1H,3H)-diones of the formula I in which: R denotes hydrogen, 6-methyl, 6-fluoro, 6-chloro, 6-bromo or 6,7-dimethoxy, R denotes hydrogen or methyl and n denotes 1 or 2, including their salts and tautomers, a process for their preparation and their use in pharmaceutical compositions. The compounds of the formula I are distinguished by advantageous immunostimulating or immunorestorative and antiviral activity, so that they can be employed favourably in human and veterinary medicine for the treatment of immune diseases and virus infections.

3- (Mercaptoalkyl) quinazoline-2,4 (1H, 3H) -dione, processes for their preparation and pharmaceutical preparations

Verfahren zur herstellung von 3-(mercaptoalkyl)=thieno/2,3-d/pyrimidin-2,4(1h,3h)-dionen

Verfahren zur herstellung von 3-(alkylthioalkyl)-2,4-dioxo-1,2,3,4-tetrahydro-chinazolinen

Disclosed are 3-(mercaptoalkyl)- or 3-(alkylthioalkyl)- pyrimidin-2,4(1H, 3H)-diones which exhibit an immune-stimulating and/or immune-restoring action and/or are suitable for use in the treatment of illnesses caused by phagocytose activity of granulocytes or macrophages reduced by exogenic and/or endogenic factors.

3-(mercaptoalkyl)- or 3-(alkylthioalkyl)- pyrimidin-2,4(1h, 3h)-diones

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Droessler Karl

Author Tools

Chat about Author

Papers

3- (Mercaptoalkyl) quinazoline-2,4 (1H, 3H) -dione, processes for their preparation and pharmaceutical preparations

Verfahren zur herstellung von 3-(mercaptoalkyl)=thieno/2,3-d/pyrimidin-2,4(1h,3h)-dionen

Verfahren zur herstellung von 3-(alkylthioalkyl)-2,4-dioxo-1,2,3,4-tetrahydro-chinazolinen

3-(mercaptoalkyl)- or 3-(alkylthioalkyl)- pyrimidin-2,4(1h, 3h)-diones