Drew G. Michael
National Institutes of Health
25 Papers
13 Citations
Drew G. Michael is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Salivary gland & Biology. The author has an hindex of 12, co-authored 23 publications. Previous affiliations of Drew G. Michael include Washington University in St. Louis & George Washington University.
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Papers
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
Brian T. Edelson,Wumesh Kc,Richard Juang,Masako Kohyama,Loralyn A. Benoit,Paul A. Klekotka,Clara Moon,Jörn C. Albring,Wataru Ise,Drew G. Michael,Deepta Bhattacharya,Thaddeus S. Stappenbeck,Michael J. Holtzman,Sun-Sang J. Sung,Theresa L. Murphy,Kai Hildner,Kenneth M. Murphy +16 more
TL;DR: Evidence is provided for a developmental relationship between lymphoid organ–resident CD8α+ cDCs and nonlymphoid CD103+ DCs and their shared developmental dependence on the transcription factor Irf8.
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LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.
Tsutomu Tanaka,Blake M. Warner,Drew G. Michael,Hiroyuki Nakamura,Toshio Odani,Hongen Yin,Tatsuya Atsumi,Masayuki Noguchi,John A. Chiorini +8 more
TL;DR: In this paper, the effect of LAMP3 expression in minor salivary gland cells was examined and it was found that increased LAMP1 expression resulted in degradation of lysosomal membrane permeabilization and relocalization of cathepsins to the cytoplasm, resulting in destabilizing autophagic flux and caspase activation.
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Model-based transcriptome engineering promotes a fermentative transcriptional state in yeast
Drew G. Michael,Ezekiel J. Maier,Holly Brown,Stacey R. Gish,Christopher Fiore,Randall H. Brown,Michael R. Brent +6 more
TL;DR: An integrated model of transcriptional regulation and metabolic flux is presented that will enable future efforts aimed at improving xylose fermentation to prioritize functional regulators of central carbon metabolism.
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Microarray analysis of sexually dimorphic gene expression in human minor salivary glands
Drew G. Michael,Sameer Soi,J Cabera-Perez,Melodie L. Weller,Stefanie Alexander,Ilias Alevizos,Gabor G. Illei,John A. Chiorini +7 more
TL;DR: Analysis of transcriptome of minor salivary glands from normal male and female volunteers identified a number of gender, species, and tissue-specific gene expression patterns involved in immune modulation, chemotactic control, inhibition of complement, metabolism, and neurogenesis that may be involved in the development of Sjögren's syndrome.
Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren’s syndrome
Y. Mo,Hiroyuki Nakamura,Tsutomu Tanaka,Toshio Odani,Paola Pérez,Y. Ji,Benjamin N French,Thomas Pranzatelli,Drew G. Michael,Hongen Yin,Susan S. Chow,Maryam Khalaj,Sandra Afione,Changyu Zheng,Fabiola Reis Oliveira,Ana Carolina Fragoso Motta,Alfredo Ribeiro-Silva,Eduardo Rocha,Cuong Q. Nguyen,Masayuki Noguchi,Tatsuya Atsumi,Blake M. Warner,John A. Chiorini +22 more
TL;DR: The newly identified LAMP3/HSP70/BMP6 axis provided an etiological model for SS gland dysfunction and autoimmunity and showed that HSP70 was an endogenous natural TLR4 ligand that stimulated BMP6 expression in SS.
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