SARC-F: a simple questionnaire to rapidly diagnose sarcopenia.

The new ICD-10-CM (M62.84) code for sarcopenia represents a major step forward in recognizing sarcopenia as a disease. This should lead to an increase in availability of diagnostic tools and the enthusiasm for pharmacological companies to develop drugs for sarcopenia.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcsm.12147

Welcome to the ICD-10 code for sarcopenia.

// Mariana Janini Gomes 1 , Paula Felippe Martinez 2 , Luana Urbano Pagan 1 , Ricardo Luiz Damatto 1 , Marcelo Diacardia Mariano Cezar 1 , Aline Regina Ruiz Lima 1 , Katashi Okoshi 1 and Marina Politi Okoshi 1 1 Botucatu Medical School, Internal Medicine Departament, Sao Paulo State University, UNESP, Botucatu, SP, Brazil 2 School of Physical Therapy, Federal University of Mato Grosso do Sul, Campo Grande, Brazil Correspondence to: Marina Politi Okoshi, email: // Keywords : elderly, physical capacity, sarcopenia, training, treatment Received : November 04, 2016 Accepted : January 09, 2017 Published : January 15, 2017 Abstract Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations.

/pdf/skeletal-muscle-aging-influence-of-oxidative-stress-and-2dw1r47bfa.pdf

Skeletal muscle aging: influence of oxidative stress and physical exercise.

Defining sarcopenia in terms of incident adverse outcomes.

Nutrition in geriatrics.

We present an application of a quantitative systems pharmacology (QSP) model to support a regulatory decision, specifically in assessing the adequacy of the proposed dosing regimen. On January 23, 2015, the US Food and Drug Administration (FDA) approved Natpara (human parathyroid hormone (PTH)) to control hypocalcemia in patients with hypoparathyroidism. Clinical trial results indicated that although once-daily PTH reduced calcium and vitamin D dose requirement while maintaining the normocalcemia, the regimen was not adequate to control hypercalciuria. We hypothesized that the lack of control on urinary calcium excretion was due to the short half-life of PTH. The QSP model-based simulations indicated that a more frequent dosing regimen may provide better control on hypercalciuria while maintaining normocalcemia. A postmarketing trial was recommended to assess pharmacokinetics (PKs) and pharmacodynamics (PDs) of PTH dose and dosing regimen. Although other modeling approaches may be feasible, in this specific case, QSP model-based simulations fulfilled the information gap to support recommendations of this postmarketing trial.

Use of a Systems Pharmacology Model Based Approach Toward Dose Optimization of Parathyroid Hormone Therapy in Hypoparathyroidism.

Sarcopenia: what's in a name?

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Use of a Systems Pharmacology Model Based Approach Toward Dose Optimization of Parathyroid Hormone Therapy in Hypoparathyroidism.

Sarcopenia: what's in a name?