OBJECTIVE:To review the efficacy and safety of fenofibrate in the management of hyperlipidemias.DATA SOURCES:A MEDLINE search (1974–October 1998), Current Contents search, additional references from article bibliographies, and the package insert from the manufacturer were used to identify data for evaluation. Studies evaluating fenofibrate (peer-reviewed publications, package insert data) were considered for inclusion. Abstracts and data on file with the manufacturer were not considered for inclusion.STUDY SELECTION:English-language literature was reviewed to evaluate the pharmacology, pharmacokinetics, clinical use, and tolerability of fenofibrate. Data from animals and in vitro systems were included only when necessary to explain the drug's pharmacology.DATA SYNTHESIS:Micronized fenofibrate is a fibric acid derivative approved by the Food and Drug Administration (FDA) in February 1998 for the treatment of types IV and V hyperlipidemia. Data from the peer-reviewed literature also support the use of fenof...

Micronized Fenofibrate: A New Fibric Acid Hypolipidemic Agent

Effect of fenofibrate on apolipoprotein B containing lipoprotein particles.

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Effect of fenofibrate on apolipoprotein B containing lipoprotein particles.