Douglas F. Easton
University of Cambridge
923 Papers
9.4K Citations
Douglas F. Easton is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 165, co-authored 844 publications. Previous affiliations of Douglas F. Easton include University of Southern California & McGill University.
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Papers
TGF-β Signaling Pathway and Breast Cancer Susceptibility
Serena Scollen,Craig Luccarini,Caroline Baynes,Kristy Driver,Manjeet K. Humphreys,Montserrat Garcia-Closas,Jonine D. Figueroa,Jolanta Lissowska,Paul D.P. Pharoah,Douglas F. Easton,Robin Hesketh,James C. Metcalfe,Alison M. Dunning +12 more
TL;DR: Common variation in the TGF-β ALK5/SMADs 2&3 signaling pathway, which initiates signaling at the cell surface to inhibit cell proliferation, might be related to risk of specific tumor subtypes.
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Evaluating the power to discriminate between highly correlated snps in genetic association studies
TL;DR: A method to estimate the sample size needed to discriminate between a functional variant of a given allele frequency and effect size, and other correlated variants is presented.
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Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk
Iris Kramer,Maartje J. Hooning,Nasim Mavaddat,Michael Hauptmann,Renske Keeman,Ewout W. Steyerberg,Daniele Giardiello,Antonis C. Antoniou,Paul D.P. Pharoah,Sander Canisius,Zumuruda Abu-Ful,Irene L. Andrulis,Hoda Anton-Culver,Kristan J. Aronson,Annelie Augustinsson,Heiko Becher,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Natalia Bogdanova,Stig E. Bojesen,Manjeet K. Bolla,Bernardo Bonanni,Hiltrud Brauch,Michael Bremer,Sara Y. Brucker,Barbara Burwinkel,Jose E. Castelao,Tsun Leung Chan,Jenny Chang-Claude,Stephen J. Chanock,Georgia Chenevix-Trench,Ji Yeob Choi,Christine L. Clarke,J. Margriet Collée,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Alison M. Dunning,Miriam Dwek,Diana Eccles,D. Gareth Evans,Peter A. Fasching,Henrik Flyger,Manuela Gago-Dominguez,Montserrat Garcia-Closas,José A. García-Sáenz,Graham G. Giles,David E. Goldgar,Anna González-Neira,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,Mikael Hartman,Bernadette A M Heemskerk-Gerritsen,Antoinette Hollestelle,John L. Hopper,Ming-Feng Hou,Anthony Howell,Abctb Investigators,kConFab Investigators,Hidemi Ito,Milena Jakimovska,Anna Jakubowska,Wolfgang Janni,Esther M. John,Audrey Y. Jung,Daehee Kang,C. Marleen Kets,Elza Khusnutdinova,Yon-Dschun Ko,Vessela N. Kristensen,Allison W. Kurian,Ava Kwong,Diether Lambrechts,Loic Le Marchand,Jingmei Li,Annika Lindblom,Jan Lubinski,Arto Mannermaa,Mehdi Manoochehri,Sara Margolin,Keitaro Matsuo,Dimitrios Mavroudis,Alfons Meindl,Roger L. Milne,Anna Marie Mulligan,Taru A. Muranen,Susan L. Neuhausen,Heli Nevanlinna,William G. Newman,Andrew F. Olshan,Janet E. Olson,Håkan Olsson,Tjoung-Won Park-Simon,Julian Peto,Christos Petridis,Dijana Plaseska-Karanfilska,Nadege Presneau,Katri Pylkäs,Paolo Radice,Gad Rennert,Atocha Romero,Rebecca Roylance,Emmanouil Saloustros,Elinor J. Sawyer,Rita K. Schmutzler,Lukas Schwentner,Christopher G. Scott,Mee-Hoong See,Mitul Shah,Chen-Yang Shen,Xiao-Ou Shu,Sabine Siesling,Susan L. Slager,Christof Sohn,Melissa C. Southey,John J. Spinelli,Jennifer Stone,William J. Tapper,Maria Tengström,Soo Hwang Teo,Mary Beth Terry,Rob A. E. M. Tollenaar,Ian Tomlinson,Melissa A. Troester,Celine M. Vachon,Chantal Van Ongeval,Elke M van Veen,Robert Winqvist,Alicja Wolk,Wei Zheng,Argyrios Ziogas,Douglas F. Easton,Per Hall,Marjanka K. Schmidt +141 more
TL;DR: PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies.
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Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Marco Matejcic,Edward J. Saunders,Tokhir Dadaev,Mark N. Brook,Kan Wang,Xin Sheng,Ali Amin Al Olama,Fredrick R. Schumacher,Sue A. Ingles,Koveela Govindasami,Sara Benlloch,Sara Benlloch,Sonja I. Berndt,Demetrius Albanes,Stella Koutros,Kenneth Muir,Kenneth Muir,Victoria L. Stevens,Susan M. Gapstur,Catherine M. Tangen,Jyotsna Batra,Jyotsna Batra,Judith A. Clements,Judith A. Clements,Henrik Grönberg,Nora Pashayan,Nora Pashayan,Johanna Schleutker,Johanna Schleutker,Johanna Schleutker,Alicja Wolk,Catharine M L West,Lorelei A. Mucci,Peter Kraft,Geraldine Cancel-Tassin,Karina Dalsgaard Sørensen,Karina Dalsgaard Sørensen,Lovise Maehle,Eli Marie Grindedal,Sara S. Strom,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,Ruth C. Travis,Robert J. Hamilton,Barry S. Rosenstein,Yong-Jie Lu,Graham G. Giles,Graham G. Giles,Adam S. Kibel,Ana Vega,Jeanette T. Bensen,Manolis Kogevinas,Kathryn L. Penney,Jong Y. Park,Janet L. Stanford,Janet L. Stanford,Cezary Cybulski,Børge G. Nordestgaard,Børge G. Nordestgaard,Hermann Brenner,Christiane Maier,Jeri Kim,Manuel R. Teixeira,Susan L. Neuhausen,Kim De Ruyck,Azad Hassan Abdul Razack,Lisa F. Newcomb,Lisa F. Newcomb,Davor Lessel,Radka Kaneva,Nawaid Usmani,Frank Claessens,Paul A. Townsend,Manuela Gago Dominguez,Monique J. Roobol,Florence Menegaux,Kay-Tee Khaw,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hardev Pandha,Stephen N. Thibodeau,Daniel J. Schaid,Fredrik Wiklund,Stephen J. Chanock,Douglas F. Easton,Rosalind A. Eeles,Zsofia Kote-Jarai,David V. Conti,Christopher A. Haiman +89 more
TL;DR: The authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.
Quantifying the genetic correlation between multiple cancer types
Sara Lindström,Sara Lindström,Hilary K. Finucane,Hilary K. Finucane,Brendan Bulik-Sullivan,Fredrick R. Schumacher,Christopher I. Amos,Rayjean J. Hung,Kristin A. Rand,Stephen B. Gruber,David V. Conti,Jennifer B. Permuth,Hui-Yi Lin,Ellen L. Goode,Thomas A. Sellers,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Alison P. Klein,Gloria M. Petersen,Harvey A. Risch,Brian M. Wolpin,Li Hsu,Jeroen R. Huyghe,Jenny Chang-Claude,Jenny Chang-Claude,Andrew T. Chan,Sonja I. Berndt,Rosalind A. Eeles,Douglas F. Easton,Christopher A. Haiman,David J. Hunter,Benjamin M. Neale,Alkes L. Price,Peter Kraft +33 more
TL;DR: For example, this paper found significant (P < 0.003) genetic correlations between pancreatic and colorectal cancer (rg = 0.55, P = 0.03 × 10-6).
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