Douglas F. Easton
University of Cambridge
923 Papers
9.4K Citations
Douglas F. Easton is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 165, co-authored 844 publications. Previous affiliations of Douglas F. Easton include University of Southern California & McGill University.
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Papers
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
Antonis C. Antoniou,Olga M. Sinilnikova,Lesley McGuffog,Sue Healey,Heli Nevanlinna,Tuomas Heikkinen,Jacques Simard,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,Susan L. Neuhausen,Yuan C. Ding,Fergus J. Couch,Xianshu Wang,Zachary S. Fredericksen,Paolo Peterlongo,Bernard Peissel,Bernardo Bonanni,Alessandra Viel,Loris Bernard,Paolo Radice,Csilla Szabo,Lenka Foretova,Michal Zikan,Kathleen Claes,Mark H. Greene,Phuong L. Mai,Gad Rennert,Flavio Lejbkowicz,Irene L. Andrulis,Irene L. Andrulis,Hilmi Ozcelik,Gord Glendon,Anne-Marie Gerdes,Mads Thomassen,Lone Sunde,Maria A. Caligo,Yael Laitman,Tair Kontorovich,Shimrit Cohen,Bella Kaufman,Efrat Dagan,Ruth Gershoni Baruch,Eitan Friedman,Katja Harbst,Gisela Barbany-Bustinza,Johanna Rantala,Hans Ehrencrona,Per Karlsson,Susan M. Domchek,Katherine L. Nathanson,Ana Osorio,Ignacio Blanco,Adriana Lasa,Javier Benitez,Ute Hamann,Frans B. L. Hogervorst,Matti A. Rookus,J. Margriet Collée,Peter Devilee,Marjolijn J. L. Ligtenberg,Rob B. van der Luijt,Cora M. Aalfs,Quinten Waisfisz,Juul T. Wijnen,Cornelis E. P. van Roozendaal,Susan Peock,Margaret Cook,Debra Frost,Clare Oliver,Radka Platte,D. Gareth Evans,Fiona Lalloo,Rosalind A. Eeles,Louise Izatt,Rosemarie Davidson,Carol Chu,Diana Eccles,Trevor Cole,Shirley Hodgson,Andrew K. Godwin,Dominique Stoppa-Lyonnet,Bruno Buecher,Méanie Léoné,Brigitte Bressac-de Paillerets,Audrey Remenieras,Olivier Caron,Gilbert M. Lenoir,Nicolas Sevenet,Michel Longy,Sandra Fert Ferrer,Fabienne Prieur,David E. Goldgar,Alexander Miron,Esther M. John,Esther M. John,Saundra S. Buys,Mary B. Daly,John L. Hopper,Mary Beth Terry,Yosuf Yassin,Christian F. Singer,Daphne Gschwantler-Kaulich,Christine Staudigl,Thomas Hansen,Rosa B. Barkardottir,Tomas Kirchhoff,Prodipto Pal,Kristi Kosarin,Kenneth Offit,Marion Piedmonte,Gustavo C. Rodriguez,Katie Wakeley,John F. Boggess,Jack Basil,Peter E. Schwartz,Stephanie V. Blank,Amanda E. Toland,Marco Montagna,Cinzia Casella,Evgeny N. Imyanitov,Anna Allavena,Rita K. Schmutzler,Beatrix Versmold,Christoph Engel,Alfons Meindl,Nina Ditsch,Norbert Arnold,Dieter Niederacher,Helmut Deißler,Britta Fiebig,Christian Suttner,Ines Schönbuchner,Dorothea Gadzicki,Trinidad Caldés,Miguel de la Hoya,Karen A. Pooley,Douglas F. Easton,Georgia Chenevix-Trench +138 more
TL;DR: The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers and there was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not.
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The ACE gene and Alzheimer's disease susceptibility
Yolanda Narain,Agustin G. Yip,Terence Murphy,Carol Brayne,Douglas F. Easton,John Grimley Evans,John H. Xuereb,Nigel J. Cairns,Margaret M. Esiri,Robert A. Furlong,David C. Rubinsztein +10 more
TL;DR: A series of 239 necropsy confirmed late onset AD cases and elderly non-demented controls aged >73 years found significantly different ACE genotype distributions in the case and control groups, and found no evidence for an interaction between the APOE andACE loci.
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Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
Mia M. Gaudet,Karoline Kuchenbaecker,Joseph Vijai,Robert J. Klein,Tomas Kirchhoff,Lesley McGuffog,Daniel Barrowdale,Alison M. Dunning,Andy C. H. Lee,Joe Dennis,Sue Healey,Ed Dicks,Penny Soucy,Olga M. Sinilnikova,Vernon S. Pankratz,Xianshu Wang,Ronald C. Eldridge,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Frans B. L. Hogervorst,Susan Peock,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,kConFab Investigators,Paolo Peterlongo,Rita K. Schmutzler,Katherine L. Nathanson,Marion Piedmonte,Christian F. Singer,Mads Thomassen,Thomas Hansen,Susan L. Neuhausen,Ignacio Blanco,Mark H. Greene,Judith Garber,Jeffrey N. Weitzel,Irene L. Andrulis,Irene L. Andrulis,David E. Goldgar,Emma D'Andrea,Trinidad Caldés,Heli Nevanlinna,Ana Osorio,Elizabeth J. van Rensburg,Adalgeir Arason,Gad Rennert,Ans M.W. van den Ouweland,Annemarie H. van der Hout,Carolien M. Kets,Cora M. Aalfs,Juul T. Wijnen,Margreet G. E. M. Ausems,Hebon,Embrace,Debra Frost,Steve Ellis,Elena Fineberg,Radka Platte,D. Gareth Evans,Chris Jacobs,Julian Adlard,Marc Tischkowitz,Mary Porteous,Francesca Damiola,Lisa Golmard,Laure Barjhoux,Michel Longy,Muriel Belotti,Sandra Fert Ferrer,Sylvie Mazoyer,Amanda B. Spurdle,Siranoush Manoukian,Monica Barile,Maurizio Genuardi,Norbert Arnold,Alfons Meindl,Christian Sutter,Barbara Wappenschmidt,Susan M. Domchek,Georg Pfeiler,Eitan Friedman,Uffe Birk Jensen,Mark E. Robson,Sohela Shah,Conxi Lázaro,Phuong L. Mai,Javier Benitez,Melissa C. Southey,Marjanka K. Schmidt,Peter A. Fasching,Julian Peto,Manjeet K. Humphreys,Qin Wang,Kyriaki Michailidou,Elinor J. Sawyer,Barbara Burwinkel,Barbara Burwinkel,Pascal Guénel,Pascal Guénel,Stig E. Bojesen,Roger L. Milne,Hermann Brenner,Magdalena Lochmann,Kristiina Aittomäki,Thilo Dörk,Sara Margolin,Arto Mannermaa,Diether Lambrechts,Jenny Chang-Claude,Paolo Radice,Graham G. Giles,Graham G. Giles,Christopher A. Haiman,Robert Winqvist,Peter Devillee,Montserrat Garcia-Closas,Montserrat Garcia-Closas,Nils Schoof,Maartje J. Hooning,Angela Cox,Paul D.P. Pharoah,Anna Jakubowska,Nick Orr,Anna González-Neira,Guillermo Pita,M. Rosario Alonso,Per Hall,Fergus J. Couch,Jacques Simard,David Altshuler,David Altshuler,Douglas F. Easton,Georgia Chenevix-Trench,Antonis C. Antoniou,Kenneth Offit +135 more
TL;DR: A comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers and may have clinical utility for women with BRCa2 mutations weighing options for medical prevention of breast cancer.
Mutations in the Gene Encoding the Sigma 2 Subunit of the Adaptor Protein 1 Complex, AP1S2, Cause X-Linked Mental Retardation
Patrick S. Tarpey,Claire Stevens,Jon W. Teague,Sarah Edkins,Sarah O’Meara,Tim Avis,Syd Barthorpe,Gemma Buck,Adam Butler,Jennifer Cole,Ed Dicks,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David T. Jones,Andrew Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,David S. Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Sofie West,Sara Widaa,Andrew D. Yates,Rachael Catford,Julia Butler,Uma Mallya,Jenny Moon,Ying Luo,Huw Dorkins,Deborah J. Thompson,Douglas F. Easton,Richard Wooster,Martin Bobrow,N. J. Carpenter,Richard J. Simensen,Charles E. Schwartz,Roger E. Stevenson,Gillian Turner,Michael Partington,Jozef Gecz,Michael R. Stratton,P. Andrew Futreal,F. Lucy Raymond +48 more
TL;DR: Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function.
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No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer.
Alison M. Dunning,Simon McBride,Jane Gregory,Francine Durocher,Nicola A. Foster,Catherine S. Healey,Neil R. Smith,Paul D.P. Pharoah,Robert Luben,Douglas F. Easton,Bruce A.J. Ponder +10 more
TL;DR: None of the AR or VDR polymorphisms investigated has a major effect on risk of breast cancer in the British population.
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