Douglas E. Gaasterland
National Institutes of Health
72 Papers
718 Citations
Douglas E. Gaasterland is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Glaucoma & Intraocular pressure. The author has an hindex of 36, co-authored 72 publications. Previous affiliations of Douglas E. Gaasterland include Georgetown University Medical Center & Harvard University.
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Papers
The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration
Fred Ederer,Ma,Douglas E. Gaasterland,E. Kenneth Sullivan,Allen D. Beck,Bruce E. Prum,Marshall N. Cyrlin,Howard S. Weiss +7 more
TL;DR: In both analyses low intraocular pressure is associated with reduced progression of visual field defect, supporting evidence from earlier studies of a protective role for low intracular pressure in visual field deterioration.
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Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study.
Kouros Nouri-Mahdavi,D. Hoffman,Anne L. Coleman,Gang Liu,Gang Li,Douglas E. Gaasterland,Joseph Caprioli +6 more
TL;DR: Both increasing age and greater IOP fluctuation increase the odds of VF progression by 30% (for each 5-year increment in age and 1-mmHg increase in IOP fluctuations), and the higher risk conferred by Iop fluctuation was consistently observed in eyes with and without a history of cataract extraction.
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Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
Janey L. Wiggs,Brian L. Yaspan,Michael A. Hauser,Jae H. Kang,R. Rand Allingham,Lana M. Olson,Wael Abdrabou,Baojian Fan,Dan Y. Wang,Wendy Brodeur,Donald L. Budenz,Joseph Caprioli,Andrew Crenshaw,Kristy Crooks,E. DelBono,Kimberly F. Doheny,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Cathy C. Laurie,Richard K. Lee,Paul R. Lichter,Stephanie Loomis,Yutao Liu,Felipe A. Medeiros,Catherine A. McCarty,Daniel B. Mirel,Sayoko E. Moroi,David C. Musch,Anthony Realini,Frank W. Rozsa,Joel S. Schuman,Kathleen M. Scott,Kuldev Singh,Joshua D. Stein,Edward H. Trager,Paul C. VanVeldhuisen,Douglas Vollrath,Gadi Wollstein,Sachiko Yoneyama,Kang Zhang,Robert N. Weinreb,Jason Ernst,Manolis Kellis,Tomohiro Masuda,Donald J. Zack,Julia E. Richards,Margaret A. Pericak-Vance,Louis R. Pasquale,Jonathan L. Haines +49 more
TL;DR: The authors performed a meta-analysis of two independent genome-wide association studies for primary open angle glaucoma (POAG) followed by a normal pressure (NPG) defined by intraocular pressure (IOP) less than 22 mmHg subgroup analysis.
Genome-wide association analysis identifies TXNRD2 , ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma
Jessica N. Cooke Bailey,Stephanie Loomis,Jae H. Kang,R. Rand Allingham,Puya Gharahkhani,Chiea Chuen Khor,Chiea Chuen Khor,Kathryn P. Burdon,Kathryn P. Burdon,Hugues Aschard,Daniel I. Chasman,Robert P. Igo,Pirro G. Hysi,Craig A. Glastonbury,Allison E. Ashley-Koch,Murray H. Brilliant,Andrew A. Brown,Donald L. Budenz,Alfonso Buil,Ching-Yu Cheng,Ching-Yu Cheng,Hyon K. Choi,William G. Christen,Gary C. Curhan,Immaculata De Vivo,John H. Fingert,Paul J. Foster,Paul J. Foster,Charles S. Fuchs,Douglas E. Gaasterland,Terry Gaasterland,Alex W. Hewitt,Frank B. Hu,David J. Hunter,Anthony P Khawaja,Richard K. Lee,Zheng Li,Paul R. Lichter,David A. Mackey,David A. Mackey,Peter McGuffin,Paul Mitchell,Sayoko E. Moroi,Shamira A. Perera,Shamira A. Perera,Keating W. Pepper,Qibin Qi,Tony Realini,Julia E. Richards,Paul M. Ridker,Eric B. Rimm,Robert Ritch,Marylyn D. Ritchie,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Yeunjoo E. Song,Rulla M. Tamimi,Fotis Topouzis,Ananth C. Viswanathan,Shefali S. Verma,Douglas Vollrath,Jie Jin Wang,Nicole Weisschuh,Bernd Wissinger,Gadi Wollstein,Tien Yin Wong,Tien Yin Wong,Brian L. Yaspan,Donald J. Zack,Kang Zhang,Robert N. Weinreb,Margaret A. Pericak-Vance,Kerrin S. Small,Christopher J Hammond,Tin Aung,Tin Aung,Yutao Liu,Eranga N. Vithana,Eranga N. Vithana,Stuart MacGregor,Jamie E Craig,Peter Kraft,Gareth R. Howell,Michael A. Hauser,Louis R. Pasquale,Jonathan L. Haines,Janey L. Wiggs +88 more
TL;DR: New pathways underlying POAG susceptibility are identified and new targets for preventative therapies are suggested, including TXNRD2 and ATXN2 expression in retinal ganglion cells and the optic nerve head.
Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
Janey L. Wiggs,Brian L. Yaspan,Michael A. Hauser,Jae H. Kang,R. Rand Allingham,Lana M. Olson,Wael Abdrabou,Baojian Fan,Dan Y. Wang,Wendy Brodeur,Donald L. Budenz,Joseph Caprioli,Andrew Crenshaw,Kristy Crooks,E. DelBono,Kimberly F. Doheny,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Cathy C. Laurie,Richard K. Lee,Paul R. Lichter,Stephanie Loomis,Yutao Liu,Felipe A. Medeiros,Catherine A. McCarty,Daniel B. Mirel,Sayoko E. Moroi,David C. Musch,Anthony Realini,Frank W. Rozsa,Joel S. Schuman,Kathleen M. Scott,Kuldev Singh,Joshua D. Stein,Edward H. Trager,Paul C. VanVeldhuisen,Douglas Vollrath,Gadi Wollstein,Sachiko Yoneyama,Kang Zhang,Robert N. Weinreb,Jason Ernst,Manolis Kellis,Tomohiro Masuda,Donald J. Zack,Julia E. Richards,Margaret A. Pericak-Vance,Louis R. Pasquale,Jonathan L. Haines +49 more
- 01 Apr 2012
TL;DR: It is suggested that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma, and genomic pathway analysis showed an association between the T GF-beta pathway and NPG.
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