Douglas Barrows
Rockefeller University
22 Papers
31 Citations
Douglas Barrows is an academic researcher from Rockefeller University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Douglas Barrows include Icahn School of Medicine at Mount Sinai & Columbia University.
Chat about Author
Papers
PTEN function, the long and the short of it
TL;DR: This review focuses on modes of PTEN protein regulation and ways in which perturbations in this regulation may lead to disease.
295
Establishment, maintenance, and recall of inflammatory memory.
Samantha B. Larsen,Samantha B. Larsen,Christopher J. Cowley,Sairaj M. Sajjath,Douglas Barrows,Yihao Yang,Thomas L. Carroll,Elaine Fuchs +7 more
TL;DR: In this paper, the authors investigate the role of stress-responsive transcription factors in memory recall and re-recruitment in the context of inflammatory memory. But, their work is limited to a single cell type and does not consider other types of cells.
192
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.
Daniel N. Weinberg,Phillip Rosenbaum,Xiao Chen,Douglas Barrows,Cynthia Horth,Matthew R. Marunde,Irina K. Popova,Zachary B. Gillespie,Michael-Christopher Keogh,Chao Lu,Jacek Majewski,C. David Allis +11 more
TL;DR: In this article, it was shown that DNMT3A PWWP mutants accumulate at regions containing PRC1-mediated formation of monoubiquitylated histone H2A lysine 119 (H2AK119ub).
80
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Sarah M. Mense,Douglas Barrows,Douglas Barrows,Cindy Hodakoski,Nicole Steinbach,Nicole Steinbach,David Schoenfeld,David Schoenfeld,William Su,Benjamin D. Hopkins,Tao Su,Barry Fine,Hanina Hibshoosh,Ramon Parsons +13 more
TL;DR: It is shown that PTEN suppresses cell migration and invasion by blocking PREX2 activity, and PREx2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.
67
ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.
Robert T. Williams,Rohiverth Guarecuco,Leah Gates,Douglas Barrows,Maria C. Passarelli,Bryce W. Carey,Lou Baudrier,Swarna Jeewajee,Konnor La,Benjamin Prizer,Sohail Malik,Javier Garcia-Bermudez,Xiphias Ge Zhu,Jason Cantor,Henrik Molina,Thomas L. Carroll,Robert G. Roeder,Omar Abdel-Wahab,C. David Allis,Kıvanç Birsoy +19 more
TL;DR: Functional genomics reveals a critical regulator of the nutrient stress response that may be of therapeutic value and identifies a transcription factor, Zinc Finger and BTB domain-containing protein 1 (ZBTB1), as uniquely essential under asparagine deprivation.
51