Douglas A. Lauffenburger
Massachusetts Institute of Technology
761 Papers
8.9K Citations
Douglas A. Lauffenburger is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Signal transduction. The author has an hindex of 122, co-authored 705 publications. Previous affiliations of Douglas A. Lauffenburger include Broad Institute & University of Minnesota.
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Papers
Landscape of HIV neutralization susceptibilities across tissue reservoirs.
Chuangqi Wang,Timothy E. Schlub,Wen-Han Yu,Chen S. Tan,Karl Stefic,Sara Gianella,Davey M. Smith,Douglas A. Lauffenburger,Antoine Chaillon,Boris Julg +9 more
TL;DR: Blood-based screening methods to determine viral susceptibility to bNAbs might underestimate the presence of resistant viral variants in tissues, and a new Bayesian machine-learning model that uses HIV-1 envelope sequences and approximated glycan-occupancy information as variables to quantitatively predict the half-maximal-inhibitory concentrations of bNABS is applied.
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Enhanced immune activation linked to endotoxemia in HIV-1 seronegative men who have sex with men
Christine D. Palmer,Julia Tomassilli,Michael Sirignano,Marisol Romero-Tejeda,Kelly B. Arnold,Denise Che,Douglas A. Lauffenburger,Stephanie Jost,Todd M. Allen,Kenneth H. Mayer,Marcus Altfeld +10 more
- 01 Sep 2014
TL;DR: Elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at high risk of HIV-1 acquisition is shown.
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Mathematical analysis of the macrophage response to bacterial challenge in the lung
Douglas A. Lauffenburger
- 01 Jan 1985
TL;DR: The macrophage plays a central role in host defense against bacterial invasion of the lung and it is of great clinical and scientific interest to elucidate as clearly as possible the relationship between functional properties of the macrophages and effectiveness of the defense response.
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•Journal Article
GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field
TL;DR: Quantitative Systems Pharmacology is experiencing increased application in the drug discovery and development process, and there exist critical segments of the discipline that differ dramatically in approach and a need to bring these groups together toward a common goal.
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Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data
Ioannis N. Melas,Douglas A. Lauffenburger,Leonidas G. Alexopoulos +2 more
- 01 Nov 2013
TL;DR: In this paper, the mode of action of some of the compounds extensively used in clinical trials is interrogated on the phosphoproteomic level, in an attempt to build predictive models for clinical efficacy.
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