Douglas A. Lauffenburger
Massachusetts Institute of Technology
761 Papers
8.9K Citations
Douglas A. Lauffenburger is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Signal transduction. The author has an hindex of 122, co-authored 705 publications. Previous affiliations of Douglas A. Lauffenburger include Broad Institute & University of Minnesota.
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Papers
Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates.
Bronwyn M. Gunn,Ryan P. McNamara,Lianna F. Wood,Sabian Taylor,Anush Devadhasan,Wenyu Guo,Jishnu Das,Avlant Nilsson,Amy C. Shurtleff,Sheri Dubey,Michael Eichberg,Todd J. Suscovich,Erica Ollmann Saphire,Douglas A. Lauffenburger,Beth-Ann Coller,Jakub K. Simon,Galit Alter +16 more
TL;DR: In this article , the authors exploit a break in long-term vaccine efficacy in non-human primates to identify predictors of protection against the Ebola virus, using unbiased humoral profiling that captures neutralization and Fc-mediated functions.
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Definition and Measurement of Cell Migration Coefficients
Robert T. Tranquillo,Douglas A. Lauffenburger +1 more
- 01 Jan 1990
TL;DR: The measurement of the cell migration coefficients defined in a constitutive cell flux expression first proposed by Keller and Segel are demonstrated: the random motility coefficient, μ, and the Chemotaxis coefficient, χ.
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GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field.
CJ Musante,Abernethy,SR Allerheiligen,Douglas A. Lauffenburger,MG Zager +4 more
- 01 Sep 2016
TL;DR: Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process as discussed by the authors, which is comprised of a mix of established disciplines and methods, from molecular biology to engineering to pharmacometrics.
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Stopped-flow chamber and image analysis system for quantitative characterization of bacterial population migration: Motility and chemotaxis ofEscherichia coli K12 to fucose.
TL;DR: Values for a chemotactic sensitivity coefficient and a random motility coefficient are determined from population dispersion in the absence of a chemical gradient for Escherichia coli K12 responding to fucose, useful for predicting population behavior in application systems such as biofilm development, population dynamics of genetically-engineered bacteria released into the environment, and in situ bioremediation technologies.
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Functional Antibodies in COVID-19 Convalescent Plasma
Jonathan D. Herman,Jonathan D. Herman,Chuangqi Wang,Carolin Loos,Carolin Loos,Hyun Ah Yoon,Johanna Rivera,M. Eugenia Dieterle,Denise Haslwanter,Rohit K. Jangra,Robert H. Bortz,Katharine J. Bar,Boris Julg,Kartik Chandran,Liise Anne Pirofski,Douglas A. Lauffenburger,Galit Alter +16 more
TL;DR: In this paper, the SARS-CoV-2-specific Fc-response in CCP donors, along with the recipients prior to and after CCP transfer, revealing striking SARS CoV2 specific Fcheterogeneity across CCP units and their recipients.