Douglas A. Lauffenburger
Massachusetts Institute of Technology
761 Papers
8.9K Citations
Douglas A. Lauffenburger is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Signal transduction. The author has an hindex of 122, co-authored 705 publications. Previous affiliations of Douglas A. Lauffenburger include Broad Institute & University of Minnesota.
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Papers
Mathematical Model for the Effects of Epidermal Growth Factor Receptor Trafficking Dynamics on Fibroblast Proliferation Responses
TL;DR: The ability to predict cell proliferation as a function of serum growth factors such as EGF could lead to the designed development of cells with optimized growth responses and may also aid in elucidation of mechanisms underlying loss of normal cell proliferation control in malignant transformation.
115
Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics
Manu P. Kumar,Jinyan Du,Georgia Lagoudas,Yang Jiao,Andrew J. Sawyer,Daryl C. Drummond,Douglas A. Lauffenburger,Andreas Raue +7 more
- 01 Nov 2018
TL;DR: An approach to characterize communication by ligand-receptor interactions across all cell types in a microenvironment using single-cell RNA sequencing is presented, providing a tool for studying cell-cell interactions, their variability across tumors, and their relationship to outcome.
114
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.
Aaron S. Meyer,Shannon K. Hughes-Alford,Jennifer E. Kay,Amalchi Castillo,Alan Wells,Frank B. Gertler,Douglas A. Lauffenburger +6 more
TL;DR: In breast cancer cells, growth factor stimulation of membrane protrusion was a better predictor of 3D migration than 2D motility, cognate receptor expression, or receptor activation.
Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.
Blanche C. Ip,Nicholas A. Cilfone,Anna C. Belkina,Jason DeFuria,Madhumita Jagannathan-Bogdan,Min Zhu,Ramya Kuchibhatla,Marie E. McDonnell,Qiang Xiao,Thomas B. Kepler,Caroline M. Apovian,Douglas A. Lauffenburger,Barbara S. Nikolajczyk +12 more
TL;DR: The authors hypothesized that cytokine profiles from circulating T cells identify T cell subsets and T cell cytokines that define T2DM-associated inflammation and identified dominant sources of T cell inflammation in humans.
A mammalian functional-genetic approach to characterizing cancer therapeutics
Hai Jiang,Justin R. Pritchard,Richard T. Williams,Douglas A. Lauffenburger,Michael T. Hemann +4 more
TL;DR: In this paper, RNA interference (RNAi)-based strategy was used to characterize small-molecule function in mammalian cells, by examining the response of cells expressing short hairpin RNAs (shRNAs) to a diverse selection of chemotherapeutics.