Dosuke Iwadate
7 Papers
8 Citations
Dosuke Iwadate is an academic researcher. The author has contributed to research in topics: Biology & Pancreatic cancer. The author has an hindex of 1, co-authored 1 publications.
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Papers
Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment
Keisuke Yamamoto,Dosuke Iwadate,Hiroyuki S. Kato,Yousuke Nakai,Keisuke Tateishi,Mitsuhiro Fujishiro +5 more
TL;DR: This review summarizes the mechanisms by which PDAC cells utilize limited nutrients to maximize their growth and obtain nutrients from inside and outside the cells to thrive in a nutrient-scarce microenvironment, with a particular focus on the roles of autophagy in the pathogenesis of PDAC.
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HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers
Hiroyuki S. Kato,Keisuke Tateishi,Dosuke Iwadate,Keisuke Yamamoto,Hiroaki Fujiwara,Takuma Nakatsuka,Yotaro Kudo,Yoku Hayakawa,Hideaki Ijichi,Motoyuki Otsuka,Takahiro Kishikawa,Ryota Takahashi,Koji Miyabayashi,Yousuke Nakai,Yoshihiro Hirata,Atsushi Toyoda,Shinichi Morishita,Mitsuhiro Fujishiro +17 more
TL;DR: In this paper , the authors analyzed the relationship between 3D genome structures and the molecular subtypes of human pancreatic cancer using Hi-C analysis and found that forcing expression of HNF1B in squamous-type PC organoids induced the upregulation and downregulation of genes associated with progenitor and squamous subtypes, respectively.
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Abstract A069: Hi-C analysis in patient-derived organoids reveals the impact of three-dimensional chromatin structures on pancreatic cancer transcriptional subtypes
Hiroyuki S. Kato,Dosuke Iwadate,Keisuke Yamamoto,Hiroaki Fujiwara,Hideaki Ijichi,Mitsuhiro Fujishiro,Keisuke Tateishi +6 more
TL;DR: Kato et al. as discussed by the authors investigated the role of 3D epigenetic regulation in pancreatic cancer and found that HNF1B, a transcription factor implicated in the progenitor subtype, was sufficient to induce subtype switch, together with their underlying 3D genome structure alterations.
Autophagy as a critical driver of metabolic adaptation, therapeutic resistance, and immune evasion of cancer
Dosuke Iwadate,Eri Naito,Keisuke Tateishi,Mitsuhiro Fujishiro +3 more
TL;DR: Autophagy drives cancer adaptation, resistance to therapy, and immune evasion by supporting tumor metabolism and protecting cancer cells from stress, nutrient deprivation, and antitumor immunity, highlighting its potential as a therapeutic target in cancer treatment.