Dorothee Müller
University of Ulm
6 Papers
34 Citations
Dorothee Müller is an academic researcher from University of Ulm. The author has contributed to research in topics: Antigen & DNA. The author has an hindex of 5, co-authored 6 publications.
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Papers
DNA recognition site analysis of Xenopus wingedhelix proteins
TL;DR: Three members of the recently described XFD (Xenopus fork head domain related) multigene family in the frog Xenopus laevis that contain this DNA-binding domain have been studied and the possible role of specific nucleotides within the target site in binding the protein is discussed.
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Regions of SV40 large T antigen necessary for oligomerization and complex formation with the cellular oncoprotein p53.
TL;DR: Using SV40 mutants coding for T antigen fragments, it is found that a region between amino acids 114 and 152 and a C‐terminal region up to amino acid 669 are essential for the formation of high Mr oligomers of T antigen.
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The phosphorylation at Thr 124 of simian virus 40 large T antigen is crucial for its oligomerization.
TL;DR: The hypothesis that the oligomerization of T antigen seems to be implicated in viral DNA replication is supported.
12
The AT-rich sequence of the SV40 control region influences the binding of SV40 T antigen to binding sites II and III.
TL;DR: During lytic infection SV40 T antigen binds specifically to three different regions of the SV40 DNA to initiate DNA replication and to regulate early and late transcription.
10
SV40 T-antigen binding to site II is functionally separated from binding to site I.
TL;DR: The hypothesis that distinctly different subclasses of T-antigen binding to site I or site II may exist is supported, as it is found that shortly after infection the amount of bound DNA increased with the concentration of T antigen reaching a steady-state level at about 20 hr after infection.
9