Dorota Maciag
Jagiellonian University
14 Papers
82 Citations
Dorota Maciag is an academic researcher from Jagiellonian University. The author has contributed to research in topics: Chemistry & Piperazine. The author has an hindex of 8, co-authored 14 publications. Previous affiliations of Dorota Maciag include Jagiellonian University Medical College.
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Papers
Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.
Tomasz Dylag,Małgorzata Zygmunt,Dorota Maciag,Jadwiga Handzlik,Marek Bednarski,Barbara Filipek,Katarzyna Kieć-Kononowicz +6 more
TL;DR: Water-soluble compounds, containing 2-methoxyphenylpiperazine group (11a, 19a), showed strong antiarrhythmic properties in adrenaline-induced arrhythmia; compound 9a {1-[3-(4-(3-chloro-phenyl)-piperazin-1-yl)- 2-hydroxy-propyl]- 3-ethyl-2,4-dioxo-5,5-diphenyl-
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Synthesis and Pharmacological Evaluation of New 1-[3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one Derivatives with Anti-arrhythmic, Hypotensive, and α-Adrenolytic Activity
TL;DR: It was found that the presence of the piperazine ring and a hydroxy group in the second position of the propyl chain are critical structural features in determining the affinity of the compounds tested.
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•Journal Article
Pharmacological properties of some aminoalkanolic derivatives of xanthone.
TL;DR: A series of appropriate aminoisopropanoloxy derivatives of 2-, 3- or 6-xanthone was synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX).
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Synthesis and development of new 2-substituted 1-[3-(4-arylpiperazin-1-yl)propyl]-pyrrolidin-2-one derivatives with antiarrhythmic, hypotensive, and α-adrenolytic activity
TL;DR: A preliminary molecular modelling study suggested that the selected alpha1-AR antagonist distances and angles between pharmacophoric features, estimated for the tested compounds, were in good agreement with the parameters evaluated for ligands.
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Synthesis, physicochemical and anticonvulsant properties of new N-(pyridine-2-yl) derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione. Part II.
TL;DR: The correlation between the lipophilicity and anticonvulsant activity was obtained – the higher the lipphilicity the stronger the anticonVulsant efficacy.
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