Doris Schnabel
University of Bonn
12 Papers
234 Citations
Doris Schnabel is an academic researcher from University of Bonn. The author has contributed to research in topics: Complementary DNA & Androgen. The author has an hindex of 11, co-authored 12 publications.
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Papers
Molecular Cloning and Characterization of a Full-length Complementary DNA Encoding Human Acid Ceramidase IDENTIFICATION OF THE FIRST MOLECULAR LESION CAUSING FARBER DISEASE
Jürgen Koch,Sabine Gärtner,Chi-Ming Li,Lothar E. Quintern,Katussevani Bernardo,Orna Levran,Doris Schnabel,Robert J. Desnick,Edward H. Schuchman,Konrad Sandhoff +9 more
TL;DR: A homoallelic point mutation (T222K) was also identified in the AC gene of a patient suffering from Farber disease, further confirming the authenticity of the full-length cDNA.
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Osteoblast-Derived Factors Induce Androgen-Independent Proliferation and Expression of Prostate-Specific Antigen in Human Prostate Cancer Cells
Natalie Blaszczyk,Bassam A. Masri,Nasrin R. Mawji,Takeshi Ueda,Gavan McAlinden,Clive P. Duncan,Nicholas Bruchovsky,Hans-Udo Schweikert,Doris Schnabel,Edward C. Jones,Marianne D. Sadar +10 more
TL;DR: Osteoblasts secrete factors that cause androgen-independent induction of PSA gene expression and proliferation of prostate cancer cells by a mechanism that partially relies on the AR, and identifying such molecular mechanisms may lead to improved clinical management of metastatic prostate cancer.
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A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB.
TL;DR: In a patient with an immunologically proven GM2 activator protein deficiency, A T412 → C transition was found in the coding sequence, which results in the substitution of Arg for the normal Cys107 in the mature GM2 Activator protein.
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Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1
Sedika Issa,Doris Schnabel,Maritta Feix,Lutz Wolf,Hans E. Schaefer,David W. Russell,H. U. Schweikert +6 more
TL;DR: This work investigated which isozymes were expressed in first passage hOB cells cultured from bone specimens obtained from six donors, and 5α-reductase isozyme expression in genital skin fibroblasts cultured from foreskin of three males was determined.
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Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein.
Horst Klima,Akemi Tanaka,Doris Schnabel,Takeshi Nakano,Maria Schröder,Kunihiko Suzuki,Konrad Sandhoff +6 more
TL;DR: Full‐length cDNAs coding for the human GM2‐activator protein has been isolated and characterized, and its genomic structure studied in two overlapping clones in λ‐EMBL‐4 isolated from a human brain genomic library.
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