Dorien J.M. Peters
Leiden University Medical Center
171 Papers
1.1K Citations
Dorien J.M. Peters is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Autosomal dominant polycystic kidney disease & Polycystic kidney disease. The author has an hindex of 49, co-authored 159 publications. Previous affiliations of Dorien J.M. Peters include Leiden University.
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Papers
Denaturing Gradient Gel Electrophoresis (DGGE)
Jeroen H. Roelfsema,Dorien J.M. Peters +1 more
- 01 Jan 2005
TL;DR: DGGE is a molecular fingerprinting method that separates polymerase chain reaction (PCR)-generated DNA products based on sequence differences that results in differential denaturing characteristics of the DNA and can be used to investigate broad phylogenies or specific target organisms such as pathogens or xenobiotics degraders.
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Common regulatory elements in the polycystic kidney disease 1 and 2 promoter regions.
Irma S. Lantinga-van Leeuwen,Wouter N. Leonhard,Hans G. Dauwerse,Hans J. Baelde,Bernard A. van Oost,Martijn H. Breuning,Dorien J.M. Peters +6 more
TL;DR: Data define a functional promoter region for Pkd1 and imply that E2F, EGRF,Ets, MZF1, Sp1, and ZBP-89 are potential key regulators of PKD1 and PKD2 in mammals in mammals.
Molecular pathways involved in injury-repair and ADPKD progression.
TL;DR: Molecular mechanisms such as proliferation, inflammation, cell differentiation, cytokines and growth factors secretion, which are activated following the renal injury to allow the remodelling of the tissue and a proper organ repair are discussed.
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LRP5 variants may contribute to ADPKD
Wybrich R Cnossen,Rene H. M. te Morsche,Alexander Hoischen,Christian Gilissen,Hanka Venselaar,Soufi Mehdi,Carsten Bergmann,Monique Losekoot,Martijn H. Breuning,Dorien J.M. Peters,Joris A. Veltman,Joris A. Veltman,Joost P.H. Drenth +12 more
TL;DR: In a cohort of 79 unrelated patients with adult-onset ADPKD, a total of four different LRP5 variants that were predicted to be pathogenic by in silico tools were identified, and luciferase activity assays presented for three L RP5 variants significant decreased signal activation of canonical Wnt signaling.
Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2
Steven J. Kunnen,Wouter N. Leonhard,Cor M. Semeins,Lukas J. A. C. Hawinkels,Christian Poelma,Peter ten Dijke,Astrid D. Bakker,Beerend P. Hierck,Dorien J.M. Peters +8 more
TL;DR: It is concluded that fluid shear stress induces autocrine TGF-β/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.