Doreen R. Glodowski
Rutgers University
5 Papers
Doreen R. Glodowski is an academic researcher from Rutgers University. The author has contributed to research in topics: Endosome & Rab. The author has an hindex of 5, co-authored 5 publications.
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Papers
EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans.
Anbing Shi,Carlos Chih Hsiung Chen,Riju Banerjee,Doreen R. Glodowski,Anjon Audhya,Christopher Rongo,Barth D. Grant +6 more
TL;DR: Caenorhabditis elegans RAB-10 functions in endocytic recycling in polarized cells, regulating basolateral Cargo transport in the intestinal epithelia and postsynaptic cargo transport in interneurons, and a requirement for EHBP-1 in R AB-10–regulated transport in both of these tissues is demonstrated.
The Ubiquitin Ligase RPM-1 and the p38 MAPK PMK-3 Regulate AMPA Receptor Trafficking
TL;DR: RPM-1 has a novel postsynaptic role in interneurons, where it regulates the trafficking of the AMPA-type glutamate receptor GLR-1 from synapses into endosomes and regulates the endosomal trafficking of AMPARs at central synapses.
RAB-10 Regulates Glutamate Receptor Recycling in a Cholesterol-dependent Endocytosis Pathway
TL;DR: It is proposed that RAB-10 and LIN-10 recycle AMPARs from intracellular endosomal compartments to synapses along distinct pathways, each with distinct sensitivities to cholesterol and the clathrin-mediated endocytosis machinery.
Distinct LIN-10 Domains Are Required for Its Neuronal Function, Its Epithelial Function, and Its Synaptic Localization
Doreen R. Glodowski,Tricia Wright,Keri Martinowich,Howard C. Chang,Douglas F. Beach,Christopher Rongo +5 more
TL;DR: The data suggest that LIN-10 uses distinct modular domains for its functions in neurons and epithelial cells and that during evolution its vertebrate ortholog Mint2 has retained the ability to direct AMPAR localization in neurons.
RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway
Donglei Zhang,Nora R. Isack,Doreen R. Glodowski,Jie Liu,Carlos Chih Hsiung Chen,X.Z. Shawn Xu,Barth D. Grant,Christopher Rongo +7 more
TL;DR: RAB-6.2, its effector LIN-10, and the retromer complex maintain synaptic strength by recycling postsynaptic glutamate receptors along the retrograde transport pathway.