Donovan Duc
University of Lausanne
4 Papers
Donovan Duc is an academic researcher from University of Lausanne. The author has contributed to research in topics: Liver X receptor & Experimental autoimmune encephalomyelitis. The author has an hindex of 4, co-authored 4 publications.
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Papers
Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis
Donovan Duc,Solenne Vigne,Jeremiah Bernier-Latmani,Yannick Yersin,Florian Ruiz,Nadia Gaïa,Stefano Leo,Vladimir Lazarevic,Jacques Schrenzel,Tatiana V. Petrova,Caroline Pot +10 more
TL;DR: It is shown that encephalitogenic Th17 cells infiltrate the colonic lamina propria before neurological symptom development in two murine MS models, active and adoptive transfer experimental autoimmune encephalomyelitis (EAE), and that disrupting myelin-specific Th17 cell trafficking to the large intestine harnesses neuroinflammation.
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Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis
Neda Haghayegh Jahromi,Luca Marchetti,Federica Moalli,Donovan Duc,Camilla Basso,Heidi Tardent,Elisa Kaba,Urban Deutsch,Caroline Pot,Federica Sallusto,Federica Sallusto,Jens V. Stein,Britta Engelhardt +12 more
TL;DR: The role of intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in the activation of naïve myelin-specific T cells and in the subsequent migration of differentiated encephalitogenic Th1 and Th17 cells across the blood-brain barrier is explored in vitro and in vivo.
Oxysterols in Autoimmunity
TL;DR: The current knowledge about the role of oxysterols during autoimmune conditions is reviewed and the implication of LXR-dependent and LXRs-independent pathways are highlighted, in particular during central nervous system autoimmunity and inflammatory bowel diseases.
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IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.
Solenne Vigne,Fanny Chalmin,Donovan Duc,Aurélie Sarah Clottu,Lionel Apetoh,Jean-Marc A. Lobaccaro,Isabelle Christen,Juan Zhang,Caroline Pot,Caroline Pot +9 more
TL;DR: Assessment of oxysterol levels in subset of CD4+ T cells and demonstrated that 25-OHC and transcript levels of its synthesizing enzyme, cholesterol 25-hydroxylase, were specifically increased in IL-27-induced type 1 regulatory T (TR1) cells showed oxysterols as pro-inflammatory mediators that dampens regulatory T cell responses and thus unleash a pro- inflammatory response.