Donna Lowe
Public Health England
12 Papers
Donna Lowe is an academic researcher from Public Health England. The author has contributed to research in topics: Senescence & Endothelial stem cell. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Donna Lowe include University of Cambridge.
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Papers
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
Steve Horvath,Junko Oshima,Junko Oshima,George M. Martin,Ake T. Lu,Austin Quach,Howard Cohen,Sarah Felton,Mieko Matsuyama,Donna Lowe,Sylwia Kabacik,James G. Wilson,Alexander P. Reiner,Anna Maierhofer,Julia Flunkert,Abraham Aviv,Lifang Hou,Andrea A. Baccarelli,Yun Li,James D. Stewart,Eric A. Whitsel,Luigi Ferrucci,Shigemi Matsuyama,Ken Raj +23 more
- 01 Jul 2018
TL;DR: A novel and highly robust DNAm age estimator for human fibroblasts, keratinocytes, buccal cells, endothelial cells, lymphoblastoid cells, skin, blood, and saliva samples that uncovered an epigenetic age acceleration with a magnitude below the sensitivity levels of other DNAm-based biomarkers.
The relationship between epigenetic age and the hallmarks of aging in human cells
Sylwia Kabacik,Donna Lowe,L. Fransen,Martin O. Leonard,Siew-Lan Ang,Christopher Whiteman,Sarah Corsi,Howard Cohen,Sarah Felton,Radhika Bali,Steve Horvath,Ken Raj +11 more
TL;DR: In this paper , the authors investigated whether epigenetic aging is the manifestation of one or more of the aging hallmarks previously identified, and they showed that although aging is distinct from cellular senescence, telomere attrition and genomic instability, it is associated with nutrient sensing, mitochondrial activity and stem cell composition.
Premature aging induced by radiation exhibits pro- atherosclerotic effects mediated by epigenetic activation of CD44 expression
Donna Lowe,Ken Raj +1 more
TL;DR: In addition to understanding why cardiovascular disease increases with age, these observations provide insights into the puzzling association between radiation and cardiovascular disease and highlight the need to consider premature aging as an additional risk of radiation to human health.
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Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose
Bjorn Baselet,Niels Belmans,Emma Coninx,Donna Lowe,Ann Janssen,Arlette Michaux,Kevin Tabury,Ken Raj,Roel Quintens,Mohammed Abderrafi Benotmane,Sarah Baatout,Pierre Sonveaux,An Aerts +12 more
TL;DR: It is shown that even low doses of IR can induce premature endothelial senescence at later time points, which may lead to the development of risk-reducing strategies to prevent IR-induced CVD, such as the use of cell cycle modulators and anti-inflammatory drugs as radioprotectors and/or radiation mitigators.
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Differential Impact of Single-Dose Fe Ion and X-Ray Irradiation on Endothelial Cell Transcriptomic and Proteomic Responses
Bjorn Baselet,Omid Azimzadeh,Nadine Erbeldinger,Mayur V. Bakshi,Till Dettmering,Ann Janssen,Svetlana Ktitareva,Donna Lowe,Arlette Michaux,Roel Quintens,Ken Raj,Marco Durante,Claudia Fournier,Mohammed Abderrafi Benotmane,Sarah Baatout,Pierre Sonveaux,Soile Tapio,An Aerts +17 more
TL;DR: Fe ions induce pro-atherosclerotic processes in ECs that are different in nature and kinetics than those induced by X-rays, highlighting radiation quality-dependent differences which can be linked to the induction and progression of cardiovascular diseases (CVD).
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